6199-20-8

Basic information

• Product Name: 1-(4-fluorophenyl)-4-(2-methylpentanoyl)piperazine
• Synonyms: 1-[4-(4-fluorophenyl)piperazin-1-yl]-2-methylpentan-1-one; 1-pentanone, 1-[4-(4-fluorophenyl)-1-piperazinyl]-2-methyl-
• CAS NO: 6199-20-8
• Molecular Formula: C₁₆H₂₃FN₂O
• Molecular Weight: 278.365
• Mol File: 6199-20-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 429°C at 760 mmHg
• Flash Point: 213.3°C
• Density: 1.093g/cm³
• Vapor Pressure: 1.45E-07mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: 1-(4-fluorophenyl)-4-(2-methylpentanoyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-4-(2-methylpentanoyl)piperazine(6199-20-8)
• EPA Substance Registry System: 1-(4-fluorophenyl)-4-(2-methylpentanoyl)piperazine(6199-20-8)

Safety Data

• Hazardous Substances Data: 6199-20-8(Hazardous Substances Data)

Upstream product

• 56-89-3 L-cystine 
• 52-90-4 L-Cysteine 
• 134861-13-5 N-(benzoylsulfide)benzamide 

Relevant articles and documents

Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in: Saccharomyces cerevisiae

New evidence on the role of H2S as a gasotransmitter suggests that the true signalling effectors are polysulfides. Both oxidized polysulfides and hydropolysulfides were synthesized and their presence in S. cerevisiae was observed for the first time. A single gene-deletant approach allowed observation of the modulation of polysulfide species and levels.

Cysteine-activated hydrogen sulfide (H2S) donors

H2S, the newly discovered gasotransmitter, plays important roles in biological systems. However, the research on H2S has been hindered by the lack of controllable H2S donors that could mimic the slow and continuous H2S generation process in vivo. Herein we report a series of cysteine-activated H2S donors. Structural modifications of these molecules can regulate the rates of H2S generation. These compounds can be useful tools in H2S research.

NON-IDENTITY OF CYSTINE LYASE WTH &β-CYSTATHIONASE IN TURNIP ROOTS

An active praparation of cystine lyase (EC 4.4.1-) was prepared from turnip roots and its substrate specificity examined.Only L-cysteine, cysteine-S-SO3, and the sulphoxides of L-djenkolic acid, S-methyl- and S-ethyl-L-cysteine were substrates.L-Cystathione, L-djenkolic acid, S-methyl- and S-ethyl-cysteines were not cleaved by this enzyme.The Km for L-cystine was 1.3 mM and L-cystathionine acted as an effective competitive inhibitor with a Ki of 0.7 mM.After dialysis against 10 mM potassium phosphate buffer pH 7.5, added pyridoxal phosphate was absolutely necessary for activity.In addition a marked stimulation was observed in the presence of ammonium sulphate.The products of the reaction were cysteine persulphide, pyruvate and presumably ammonia.The persulphide was easily demonstrated by cleavage with CN- to yield SCN- under conditions in which elemental sulphur was unreactive. Key Word Index- Brassica rapa,; Cruciferae; turnip root; cystine lyase; β-cystathionase; cystine degradation.