6199-67-3 Usage
Description
Cucurbitacin B, a tetracyclic triterpenoid, is a compound with strong antitumor activity. It is characterized by a lanostane skeleton that is multi-substituted with hydroxy, methyl, and oxo substituents, featuring unsaturation at positions 5 and 23, and an acetylated hydroxy function at C-25. Cucurbitacin B exists as a white solid.
Uses
Used in Pharmaceutical Research:
Cucurbitacin B is used as a signal transducer and activator of transcription 3 (STAT3) inhibitor for determining its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs). This application is significant in understanding the role of Cucurbitacin B in regulating cellular processes and its potential as a therapeutic agent.
Used in Entomology:
Cucurbitacin B is used as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydroxyecdysone (20E) signaling in butterflies. This application aids in studying the hormonal regulation and development of insects, particularly in the context of molting and metamorphosis.
Used in Oncology:
Cucurbitacin B is used to determine its effect on the cell viability of pancreatic cancer cell lines. This application is crucial in evaluating the potential of Cucurbitacin B as an antitumor agent, specifically in the treatment of pancreatic cancer.
Biochem/physiol Actions
Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.
Check Digit Verification of cas no
The CAS Registry Mumber 6199-67-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,9 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6199-67:
(6*6)+(5*1)+(4*9)+(3*9)+(2*6)+(1*7)=123
123 % 10 = 3
So 6199-67-3 is a valid CAS Registry Number.
InChI:InChI=1/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25?,29+,30-,31+,32+/m1/s1
