62012-54-8

Basic information

• Product Name: 2-bromo-1-methoxynaphthalene
• Synonyms: 2-bromo-1-methoxynaphthalene;1-Methoxy-2-bromonaphthalene
• CAS NO: 62012-54-8
• Molecular Formula: C₁₁H₉BrO
• Molecular Weight: 237.09256
• Mol File: 62012-54-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 161 °C(Press: 14 Torr)
• Appearance: /
• Density: 1.447±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-bromo-1-methoxynaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-1-methoxynaphthalene(62012-54-8)
• EPA Substance Registry System: 2-bromo-1-methoxynaphthalene(62012-54-8)

Safety Data

• Hazardous Substances Data: 62012-54-8(Hazardous Substances Data)

Usage

General Description

2-bromo-1-methoxynaphthalene is a chemical compound with the molecular formula C11H9BrO. It is a halogenated naphthalene derivative and is often used as a building block in organic synthesis. The presence of a bromine atom and a methoxy group on the naphthalene ring makes this compound useful for various chemical reactions, including palladium-catalyzed cross-coupling reactions. It is also used in the production of pharmaceuticals and agrochemicals, as well as in the synthesis of organic dyes and materials. 2-bromo-1-methoxynaphthalene has potential applications in the field of medicinal chemistry and material science due to its unique structural and chemical properties. Additionally, it is important to handle and use this compound with caution due to its potential hazards and toxicity.

Upstream product

• 186581-53-3 diazomethane 
• 771-15-3 2-bromo-1-naphthol 
• 74-88-4 methyl iodide 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 2216-69-5 1-Methoxynaphthalene 
• 90-15-3 α-naphthol 

Downstream Products

• 148491-01-4 3-iodo-1-methoxynaphthalene 
• 85051-83-8 2-(2'-methoxyphenoxy)-1-methoxynaphthalene 
• 19938-27-3 2-Methoxy-6-(1-methoxy-2-naphthoyl)-benzoesaeure 
• 19938-26-2 3-Methoxy-2-(1-methoxy-2-naphthoyl)-benzoesaeure 
• 85051-84-9 2-(2'-hydroxyphenoxy)-1-naphthol 
• 252670-79-4 (1-methoxynaphthalen-2-yl)boronic acid 
• 604-60-4 2,2'-binaphthol 
• 1608458-02-1 C₁₈H₁₉ClO₂ 

Relevant articles and documents

Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus

Fatty acid-binding protein 4 (FABP4) and fatty acid-binding protein 5 (FABP5) are promising therapeutic targets for the treatment of various metabolic diseases. However, the weak potency, low selectivity over FABP3, or poor pharmacokinetic profiles of currently reported dual FABP4/5 inhibitors impeded further research. Here, we described the characterization of a series of dual FABP4/5 inhibitors with improved metabolic stabilities and physicochemical properties based on our previous studies. Among the compounds, D9 and E1 exhibited good inhibitory activities against FABP4/5 and favorable selectivity over FABP3 in vitro. In cell-based assays, D9 and E1 exerted a decrease of FABP4 secretion, a strong anti-lipolytic effect in mature adipocytes, and suppression of MCP-1 expression in THP-1 macrophages. Moreover, D9 and E1 possessed good metabolic stabilities in mouse hepatic microsomes and acceptable pharmacokinetics profiles in ICR mice. Further in vivo experiments showed that D9 and E1 could potently decrease serum FABP4 levels and ameliorate glucose metabolism disorders in obese diabetic db/db mice. These results demonstrated that D9 and E1 could serve as lead compounds for the development of novel anti-diabetic drugs.

Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor

Fatty acid binding protein 4 (FABP4) and fatty acid binding protein 5 (FABP5) are mainly expressed in adipocytes and/or macrophages and play essential roles in energy metabolism and inflammation. When FABP4 function is diminished, FABP5 expression is high

Computational and DNMR investigation of the isomerism and stereodynamics of the 2,2′-binaphthalene-1,1′-diol scaffold

The relative stabilities of three conformational isomers of 2,2′-binaphthalene-1,1′-diol diisobutyrate and the energy barriers to rotation about the pivotal aryl-aryl bond and the two aryl-oxygen bonds were investigated by variable-temperature NMR spectroscopy in conjunction with DFT computations. The experimental and calculated data were found to be in very good agreement and provide new insights into the dynamic stereochemistry of BINOL-derived tropos ligands.