62029-63-4

Basic information

• Product Name: 2,5,7-Tris-tert-butyl-L-tryptophan
• Synonyms: 2,5,7-Tris-tert-butyl-L-tryptophan;H-2,5,7-Tri-t-butyl-Trp-OH
• CAS NO: 62029-63-4
• Molecular Formula: C23H36N2O2
• Molecular Weight: 373
• Mol File: 62029-63-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 500.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.064
• PKA: 2.28±0.10(Predicted)
• CAS DataBase Reference: 2,5,7-Tris-tert-butyl-L-tryptophan(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5,7-Tris-tert-butyl-L-tryptophan(62029-63-4)
• EPA Substance Registry System: 2,5,7-Tris-tert-butyl-L-tryptophan(62029-63-4)

Safety Data

• Hazardous Substances Data: 62029-63-4(Hazardous Substances Data)

Usage

General Description

2,5,7-Tris-tert-butyl-L-tryptophan is a chemical compound that is a derivative of the amino acid tryptophan. It is a synthetic compound that has been modified by adding tert-butyl groups to the 2, 5, and 7 positions of the tryptophan molecule. This modification alters the chemical and physical properties of the original amino acid, potentially leading to changes in its biological activity or stability. The compound may be used in research or drug development to study the effects of tryptophan derivatives on biological systems, and its unique structure and properties make it a valuable tool for investigating the role of tryptophan in various biochemical processes.

Upstream product

• 73-22-3 L-Tryptophan 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 78654-82-7 Boc-Ttb-OH 

Relevant articles and documents

Synthetic antimicrobial peptidomimetics with therapeutic potential

A series of synthetic antimicrobial peptidomimetics (SAMPs) have been prepared and found to be highly active against several Gram-negative and Gram-positive bacterial strains. These derivatives comprise the minimal structural requirements for cationic antimicrobial peptides and showed high selectivity for Gram-negative and/or Gram-positive bacteria compared to human red blood cells. We have found that SAMPs share many of the attractive properties of cationic antimicrobial peptides inasmuch that a representative SAMP was found to insert into the bilayers of large unilamellar vesicles, permeabilized both the outer and cytoplasmic membrane of Escherichia coli ML-35p, and displayed an extremely rapid bacterial killing for Staphylococcus aureus. However, while antimicrobial peptides are prone to proteolytic degradation, high in vitro stability in human blood plasma was shown for SAMPs. A combination of high antibacterial activity against methicillin-resistant staphylococci and low toxicity against human erythrocytes makes these molecules promising candidates for novel antibacterial therapeutics.

Inhibition of tumor growth

The present invention provides a cytotoxic 7 to 25 mer peptide with three or more cationic residues which has one or more non-genetic bulky and lipophilic amino acids, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of p