62030-44-8

Basic information

• Product Name: propan-2-yl pent-4-enoate
• Synonyms: 4-Pentenoic acid isopropyl ester; 4-pentenoic acid, 1-methylethyl ester; Isopropyl pent-4-enoate
• CAS NO: 62030-44-8
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.1956
• Mol File: 62030-44-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 141.9°C at 760 mmHg
• Flash Point: 43.4°C
• Density: 0.891g/cm³
• Vapor Pressure: 5.72mmHg at 25°C
• Refractive Index: 1.422
• CAS DataBase Reference: propan-2-yl pent-4-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: propan-2-yl pent-4-enoate(62030-44-8)
• EPA Substance Registry System: propan-2-yl pent-4-enoate(62030-44-8)

Safety Data

• Hazardous Substances Data: 62030-44-8(Hazardous Substances Data)

Upstream product

• 1772-43-6 2,4,4-trimethyl oxazoline 
• 67-63-0 isopropyl alcohol 
• 107-05-1 3-chloroprop-1-ene 
• 591-80-0 pent-4-enoic acid 
• 33574-02-6 cyclopropylmethyl iodide 
• 108-23-6 isopropyl chloroformate 

Downstream Products

• 1583259-44-2 (2R,3S,4R)-isopropyl 2-allyl-5-(benzyloxy)-3-hydroxy-4-(2,2,6,6-tetramethylpiperidin-1-yloxy)pentanoate 
• 1583259-43-1 (2S,3S,4R)-isopropyl 2-allyl-5-(benzyloxy)-3-hydroxy-4-(2,2,6,6-tetramethylpiperidin-1-yloxy)pentanoate 

Relevant articles and documents

Branch-Selective Addition of Unactivated Olefins into Imines and Aldehydes

Radical hydrofunctionalization occurs with ease using metal-hydride hydrogen atom transfer (MHAT) catalysis to couple alkenes and competent radicalophilic electrophiles. Traditional two-electron electrophiles have remained unreactive. Herein we report the reductive coupling of electronically unbiased olefins with imines and aldehydes. Iron catalysis allows addition of alkyl-substituted olefins into imines through the intermediacy of free radicals, whereas a combination of catalytic Co(Salt-Bu,t-Bu) and chromium salts enables a branch-selective coupling of olefins and aldehydes through the formation of a putative alkyl chromium intermediate.

A general and enantioselective approach to pentoses: A rapid synthesis of PSI-6130, the nucleoside core of sofosbuvir

An efficient route towards biologically relevant pentose derivatives is described. The de novo synthetic strategy features an enantioselective α-oxidation reaction enabled by a chiral amine in conjunction with copper(II) catalysis. A subsequent Mukaiyama aldol coupling allows for the incorporation of a wide array of modular two-carbon fragments. Lactone intermediates accessed via this route provide a useful platform for elaboration, as demonstrated by the preparation of a variety of C-nucleosides and fluorinated pentoses. Finally, this work has facilitated expedient syntheses of pharmaceutically active compounds currently in clinical use.