62037-90-5Relevant articles and documents
Nickel-catalyzed monofluoromethylation of (hetero)aryl bromides via reductive cross-coupling
Yin, Han,Sheng, Jie,Zhang, Kai-Fan,Zhang, Zi-Qi,Bian, Kang-Jie,Wang, Xi-Sheng
supporting information, p. 7635 - 7638 (2019/07/09)
A mild and efficient nickel-catalyzed direct monofluoromethylation of (hetero)aryl bromides by reductive cross-coupling has been developed. This method exhibits good efficiency, wide functional-group compatibility, and suitability for aryl and heteroaryl bromides with abundant industrial raw material BrCH2F. This strategy provides an efficient way to synthesize monofluoromethylated molecules for drug discovery.
Conformational Preference of the Fluoromethyl Group in Some Benzyl Fluorides: a 13C N.M.R. Study
Adcock, William,Abeywickrema, Anil N.
, p. 181 - 187 (2007/10/02)
A number of model benzyl fluoride systems have been synthesized, end their proton-decoupled natural-abundance 13C n.m.r. spectra recorded and assigned.An analysis of the long-range five-bond coupling constants (5JCF) indicates that these parame