6208-35-1

Basic information

• Product Name: 3-(3,4-dichlorophenyl)-5-hydroxymethylisoxazole
• Synonyms: 3-(3,4-dichlorophenyl)-5-hydroxymethylisoxazole
• CAS NO: 6208-35-1
• Molecular Weight: 244.077
• Mol File: 6208-35-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-(3,4-dichlorophenyl)-5-hydroxymethylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dichlorophenyl)-5-hydroxymethylisoxazole(6208-35-1)
• EPA Substance Registry System: 3-(3,4-dichlorophenyl)-5-hydroxymethylisoxazole(6208-35-1)

Safety Data

• Hazardous Substances Data: 6208-35-1(Hazardous Substances Data)

Upstream product

• 5331-92-0 3,4-dichlorobenzaldehyde oxime 
• 6175-54-8 hydroxy-1-propyne 
• 107-19-7 propargyl alcohol 
• 1056189-27-5 3,4-dichloro-N-hydroxybenzenecarboximidoyl chloride 
• 135294-57-4 m,p-dichlorobenzonitrile N-oxide 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 58933-36-1 3,4-dichloro-N-hydroxybenzimidoyl chloride 

Downstream Products

• 901926-64-5 3-(3,4-dichlorophenyl)-5-isoxazolylcarboxylic acid 
• 5378-65-4 3-(3,4-dichlorophenyl)-5-bromomethylisoxazole 
• 1240190-11-7 N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]methyl]-(R)-2-tert-butoxycarbonylmethylhexanamide 
• 1240190-17-3 N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]-(R)-2-methoxycarbonylmethylhexanamide 
• 1240190-22-0 (R)-2-butyl-N₄-hydroxy-N₁-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]succinamide 
• 1240190-03-7 (3-(3,4-dichlorophenyl)isoxazol-5-yl)methanamine 
• 5300-98-1 5-chloromethyl-3-(3,4-dichloro-phenyl)-isoxazole 

Relevant articles and documents

Synthesis and in vitro biological evaluation of novel coumarin derivatives containing isoxazole moieties on melanin synthesis in B16 cells and inhibition on bacteria

A novel series of coumarin derivatives 6a–o, bearing isoxazole moieties were designed and synthesized. After that, they were evaluated for melanin synthesis in murine B16 cells and inhibitory effect on the growth of CA (Candida albicans), EC (Escherichia coli), SA (Staphylococcus aureus). It was found that eleven compounds (6b–f, 6j–o) showed a better activity on melanin synthesis than positive control (8-MOP). Among them, compounds 6d (242%) and 6f (390%), with nearly 1.6 and 2.6-fold potency compared with 8-MOP (149%) respectively, were recognized as the most promising candidate hits for further pharmacological study of anti-vitiligo. Seven halogen substituted compounds exhibited moderate antimicrobial activity against CA. It is interesting that 6e–f and 6l–m, which had two halogens on the benzene showed a comparable activity with Amphotericin B against CA. The evaluation of melanin synthesis in B16 cells and inhibitory effect on bacteria of above structurally diverse derivatives had also led to an outline of structure-activity relationship.

Design, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors

A new series of N-formylhydroxylamines 11a-i have been synthesized through a multi-step protocol starting from diethyl malonate. These compounds have been structurally characterized by IR, 1H NMR and HRMS. All the synthesized compounds 11a-i have been screened for antibacterial activities. All the compounds are found to exhibit potent in vitro inhibitory activity against Staphylococcus aureus and relatively weak antibacterial activity against Klebsiella pneumoniae.

Concise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins

The synthesis of a series of new 5-isoxazolpenicillins is described, which were obtained by coupling substituted isoxazoles with 6-APA. Concise large-scale synthesis of 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition using copper(I) as catalyst was also investigated. Representative compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-negative bacteria.