6208-60-2Relevant articles and documents
Method for protecting sulfonyl of deamination amine
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Paragraph 0042-0044, (2021/11/03)
The invention discloses a method for removing sulfenyl protection of amine. The method comprises the following steps: dissolving N - sulfonyl-protected amine and a base in a reaction solvent, then adding diphenylphosphine to uniformly mix and maintain 90 °C. When TCL detection reaction is complete, a recrystallization method or an extraction separation method is adopted to obtain the target product. The method disclosed by the invention adopts diphenylphosphine as an extraction reagent, is good in reaction activity, high in selectivity and wide in application range, and can replace the use of a hazardous reagent under the basic heating condition. Prodrug research and development and industrial production are of great significance.
Thiapyran[4,3-b] indole compound and preparing method and application thereof
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Paragraph 0049; 0054; 0055, (2018/10/19)
The invention discloses a thiapyran[4,3-b] indole compound and a preparing method and application thereof. The structure of the compound is shown in the formula 1, wherein the formula 1 is shown in the description, and R1-R5 are not all hydrogen. The compound has excellent activities of inhibiting mycelial growth, protecting detached leaves, protecting living bodies and treating the living bodiesfor rhizoctonia solani, the effects of the compound are even superior to those of positive control drugs, and the compound has an important application value in preventing and/or treating rice sheathblight.
Biomimetic Oxidative Coupling Cyclization Enabling Rapid Construction of Isochromanoindolenines
Ye, Jinxiang,Lin, Yuqi,Liu, Qing,Xu, Dekang,Wu, Fan,Liu, Bin,Gao, Yu,Chen, Haijun
supporting information, p. 5457 - 5460 (2018/09/13)
Herein, we report a biomimetic oxidative coupling cyclization strategy for the highly efficient functionalization of tetrahydrocarbolines (THCs). This process enables rapid access to complex isochromanoindolenine scaffolds in moderate to excellent yields.