6208-98-6

Basic information

• Product Name: L-Glutamic acid, 3-hydroxy-, (3R)-
• CAS NO: 6208-98-6
• Molecular Formula: C5H9NO5
• Molecular Weight: 163.13
• Mol File: 6208-98-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Glutamic acid, 3-hydroxy-, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid, 3-hydroxy-, (3R)-(6208-98-6)
• EPA Substance Registry System: L-Glutamic acid, 3-hydroxy-, (3R)-(6208-98-6)

Safety Data

• Hazardous Substances Data: 6208-98-6(Hazardous Substances Data)

Usage

General Description

L-Glutamic acid, 3-hydroxy-, (3R)- is a chemical compound that belongs to the family of amino acids. It is a derivative of glutamic acid, a non-essential amino acid that plays a crucial role in protein synthesis and various metabolic processes in the body. The 3-hydroxy modification on the molecule potentially adds to its bioactivity and functionality. The (3R) configuration refers to the three-dimensional arrangement of the atoms in the compound, which can impact its biological properties and interactions with other molecules in physiological processes. Overall, L-Glutamic acid, 3-hydroxy-, (3R)- is a unique compound with promising potential for various pharmaceutical and medical applications.

Upstream product

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• 7705-08-0 iron(III) chloride 
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• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 102076-70-0 DL-erythro-N-benzoyl-3-hydroxy-glutamic acid diethyl ester 
• 19883-13-7 DL-threo-N-acetyl-3-hydroxy-glutamic acid diethyl ester 

Downstream Products

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Relevant articles and documents

Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp.

Two new HIV-inhibitory depsipeptides, stellettapeptins A (1) and B (2), were isolated from an extract of the marine sponge Stelletta sp., collected from northwestern Australia. Structures of these cyclic nonribosomal peptides were elucidated on the basis of extensive NMR data analysis, and chemical degradation and derivatization studies. Stellettapeptins contain numerous nonproteinogenic amino acid residues and they are the first peptides reported to contain a 3-hydroxy-6,8-dimethylnon-4-(Z)-enoic acid moiety. Compounds 1 and 2 potently inhibit infection of human T-lymphoblastoid cells by HIV-1RF with EC50 values of 23 and 27 nM, respectively.

FR901469, a novel antifungal antibiotic from an unidentified fungus No. 11243. III. Structure determination

A novel antifungal antibiotic, FR901469, was isolated from an unidentified fungus No. 11243. It is a water-soluble 40-membered macrocyclic lipopeptidolactone, consisting of D-Ala, L-Tyr, L-Val, trans-4OH-L-Pro, trans-3OH-L-Pro, threo-3OH-L-Gln, Gly, L-Orn, L-Thr, three residues of D-allo Thr and a (3R)-hydroxypalmitic acid. Its structure, including absolute configurations, was unequivocally determined as 1 based on chemical and spectroscopic evidence.

L-threo- and L-erythro-3-Fluoroglutamic Acids. Synthesis by Fluorodehydroxylation and Enzymatic Resolution.

threo- and erythro-3-fluoroglutamic acids were prepared by fluorodehydroxylation of N-acetyl-3-hydroxyglutamic acids according to Kollonitsch.Following ion exchange column separation of the diastereoisomers, enzymatic deacylation by acylase I afforded optically pure L-isomers of the 3-fluoroglutamic acid.Assignment of structure was achieved by correlation with cis- and trans-3-fluoropyroglutamic acids.The results indicate predominant inversion of configuration during the fluorodehydroxylation reaction.