62103-87-1

Basic information

• Product Name: 2H-1,4-Benzoxazin-2-one, 6-methyl-3-phenyl-
• CAS NO: 62103-87-1
• Molecular Formula: C15H11NO2
• Molecular Weight: 237.258
• Mol File: 62103-87-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2H-1,4-Benzoxazin-2-one, 6-methyl-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-Benzoxazin-2-one, 6-methyl-3-phenyl-(62103-87-1)
• EPA Substance Registry System: 2H-1,4-Benzoxazin-2-one, 6-methyl-3-phenyl-(62103-87-1)

Safety Data

• Hazardous Substances Data: 62103-87-1(Hazardous Substances Data)

Upstream product

• 95-84-1 3-amino-4-hydroxytoluene 
• 611-73-4 Benzoylformic acid 
• 10531-78-9 5-methyl-1,3-benzoxazole 
• 1603-79-8 phenylglyoxylic acid ethyl ester 

Downstream Products

• 7420-86-2 5-methyl-2-phenyl-1,3-benzoxazole 
• 1192308-06-7 (?)-(R)-6-methyl-3-phenyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one 
• 1335225-53-0 6-methyl-3-phenyl-3,4-dihydro-2H-1,4-benzoxazin-2-one 

Relevant articles and documents

α-Keto Acids as Triggers and Partners for the Synthesis of Quinazolinones, Quinoxalinones, Benzooxazinones, and Benzothiazoles in Water

A general and efficient method for the synthesis of quinazolinones, quinoxalinones, benzooxazinones, and benzothiazoles from the reactions of α-keto acids with 2-aminobenzamides, benzene-1,2-diamines, 2-aminophenols, and 2-aminobenzenethiols, respectively, is described. The reactions were conducted under catalyst-free conditions, using water as the sole solvent with no additive required, and successfully applied to the synthesis of sildenafil. More importantly, these reactions can be conducted on a mass scale, and the products can be easily purified through filtration and washing with ethanol (or crystallized).

Unexpected TFA-catalyzed tandem reaction of benzo[d]oxazoles with 2-oxo-2-arylacetic acids: Synthesis of 3-aryl-2H-benzo[b][1,4]oxazin-2-ones and cephalandole A

A convenient and efficient method for the TFA-catalyzed synthesis of 3-aryl-2H-benzo[b][1,4]oxazin-2-ones via a tandem reaction of benzo[d]oxazoles with 2-oxo-2-arylacetic acids was reported for the first time. The efficiency of this transformation was demonstrated by compatibility with a wide range of functional groups. The synthetic utility of this method was confirmed by the synthesis of the natural product cephalandole A. Moreover, a plausible mechanism for the formation of 3-aryl-2H-benzo[b][1,4]oxazin-2-ones involving ring-opening and cyclization steps is proposed. The present synthetic route to 3-aryl-2H-benzo[b][1,4]oxazin-2-ones could be readily scaled up to gram quantity without difficulty.