6214-31-9

Basic information

• Product Name: 3-BROMO-3-METHYL-BUT-1-YNE
• Synonyms: 3-BROMO-3-METHYL-BUT-1-YNE;3-broMo-3-Methyl-1-butyne
• CAS NO: 6214-31-9
• Molecular Formula: C₅H₇Br
• Molecular Weight: 147.01308
• Mol File: 6214-31-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-BROMO-3-METHYL-BUT-1-YNE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-3-METHYL-BUT-1-YNE(6214-31-9)
• EPA Substance Registry System: 3-BROMO-3-METHYL-BUT-1-YNE(6214-31-9)

Safety Data

• Hazardous Substances Data: 6214-31-9(Hazardous Substances Data)

Usage

General Description

3-Bromo-3-methyl-but-1-yne is a chemical compound with the molecular formula C5H7Br. It is a colorless to light yellow liquid with a pungent odor. 3-BROMO-3-METHYL-BUT-1-YNE is mainly used in organic synthesis as an intermediate to produce various other chemicals. It is also utilized in the pharmaceutical industry for the preparation of active pharmaceutical ingredients. Additionally, 3-Bromo-3-methyl-but-1-yne is used as a reagent in the production of agrochemicals and as a building block for the synthesis of specialty chemicals. It is important to handle this compound with caution, as it is flammable and can cause skin and eye irritation upon contact.

Upstream product

• 115-19-5 2-methyl-but-3-yn-2-ol 
• 78-80-8 2-methylbut-1-en-3-yne 
• 23534-96-5 1-chloro-2,2-dibromo-3,3-dimethylcyclopropane 
• 23534-97-6 1,1,3‐tribromo‐2,2‐dimethylcyclopropane 
• 108176-10-9 1-bromo-3,3-dimethylcyclopropene 

Downstream Products

• 6340-49-4 1-(1,1-dimethyl-2-propynyl)-piperidine 
• 21020-31-5 3-methyl-1-phenyl-1,2-butadiene 
• 29412-46-2 3,3-Dimethyl-4-dimethylamino-1-butin 
• 78389-99-8 5-methyl-1-(trimethylsilyl)-3,4-hexadien-1-yne 
• 78390-00-8 1-(5-methylhexa-3,4-dien-1-ynyl)benzene 
• 71-36-3 butan-1-ol 
• 65108-45-4 1-(1,1-Dimethyl-prop-2-ynyl)-cyclohexanol 
• 1118-17-8 3-tert-Butylamino-3-methyl-1-butyne 
• 7471-09-2 3-methyl-3-phenylamino-1-butyne 
• 21079-27-6 diethyl 2-(1,1-dimethyl-2-propynyl)malonate 
• 65108-32-9 2,2-dimethyl-1-phenyl-3-butyn-1-ol 
• 38517-08-7 4-methyl-1-phenyl-2,3-pentadien-1-ol 
• 7740-69-4 3-ethoxy-3-methyl-but-1-yne 
• 115-19-5 2-methyl-but-3-yn-2-ol 

Relevant articles and documents

1-HALOCYCLOPROPENES AND PROPARGYLIC HALIDES FROM THE REACTION OF TRIHALOCYCLOPROPANES WITH METHYL LITHIUM

1,1,2-Trihalocyclopropanes (halogen=chlorine or bromine) undergo 1,2-dehalogenation on reaction with methyl lithium, and in a number of cases the product is a 1-halocyclopropene.In the reactions of (20, X=Br, Cl) and (25) a rearrangement occurs even at low temperatures and propargylic halides are isolated, while (16) is converted to 2-chlorocyclohex-2-enylidene which may be trapped by furan.

Silver-Catalyzed Three-Component 1,1-Aminoacylation of Homopropargylamines: α-Additions for Both Terminal Alkynes and Isocyanides

The reaction of secondary homopropargylamines, isocyanides, and water in the presence of a catalytic amount of silver acetate and subsequent purification by chromatography on silica gel afforded substituted proline amides in good to excellent yields. Primary homopropargylamines underwent a cyclizative Ugi–Joullié three-component reaction with isocyanides and carboxylic acids to afford functionalized N-acyl proline amides. High diastereoselectivity was observed in the synthesis of 4-alkoxy and 4,5-disubstituted proline derivatives. This work represents the first examples of a three-component cyclizative 1,1-aminoacylation of terminal alkynes.

Total synthesis of bryostatins: The development of methodology for the atom-economic and stereoselective synthesis of the ring C subunit

Bryostatins, a family of structurally complicated macrolides, exhibit an exceptional range of biological activities. The limited availability and structural complexity of these molecules makes development of an efficient total synthesis particularly impor