6214-64-8Relevant articles and documents
RECYCLIZATION OF 5-CARBETHOXY-4-METHYL-2-MERCAPTO(AMINO, HYDROXY) PYRIMIDINES TO GIVE 5-ACETYL-2-MERCAPTO(AMINO, HYDROXY)-4-HYDROXYPYRIMIDINES
Vartanyan, R. S.,Kazaryan, Zh. V.,Vartanyan, S. A.
, p. 1212 - 1213 (1982)
Conditions for the selective preparation of 5-carbethoxy-4-methyl-2-substituted pyrimidines or 5-acetyl-4-hydroxy-2-substituted pyrimidines by condensation of ethoxymethyleneacetoacetic ester with 1,3-binucleophiles are proposed.It is shown that under the influence of sodium ethoxide 5-carbethoxy-4-methyl-2-substituted pyrimidines undergo rearrangement to 5-acetyl-4-hydroxy-2-substituted pyrimidines.
Synthesis of 4-aminoquinoline - Pyrimidine hybrids as potent antimalarials and their mode of action studies
Singh, Kamaljit,Kaur, Hardeep,Chibale, Kelly,Balzarini, Jan
, p. 314 - 323 (2013/10/01)
One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of
Investigation on possibility of rearrangement of pyrimidine-5-carboxylic acids esters
Scherbinina,Dar'In,Lobanov
experimental part, p. 1109 - 1115 (2011/10/02)
A previously reported rearrangement of pyrimidine-5-carboxylic acids esters to 5-acylpyrimidones does not, in fact, occur in any of the examples studied by us.