62158-88-7

Basic information

• Product Name: Benzene, 1-methoxy-4-(2,2,2-trifluoroethoxy)-
• CAS NO: 62158-88-7
• Molecular Formula: C9H9F3O2
• Molecular Weight: 206.164
• Mol File: 62158-88-7.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-4-(2,2,2-trifluoroethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-4-(2,2,2-trifluoroethoxy)-(62158-88-7)
• EPA Substance Registry System: Benzene, 1-methoxy-4-(2,2,2-trifluoroethoxy)-(62158-88-7)

Safety Data

• Hazardous Substances Data: 62158-88-7(Hazardous Substances Data)

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 623-12-1 4-chloromethoxybenzene 
• 693-02-7 hex-1-yne 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 696-62-8 para-iodoanisole 
• 422-05-9 2,2,3,3,3-pentafluoropropyl alcohol 
• 589-87-7 1,4-bromoiodobenzene 
• 420-87-1 sodium 2,2,2-trifluoroethanolate 
• 80134-77-6 4-methoxyphenyl (phenyl)iodonium phosphorus hexafluoride 
• 141339-54-0 bis(4-anisyl)iodonium triflate 
• 5720-07-0 4-methoxyphenylboronic acid 
• 93131-74-9 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonic acid 4-methoxyphenyl ester 
• 762-72-1 allyl-trimethyl-silane 

Relevant articles and documents

Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C-O Cross-Coupling

Herein, we report a highly effective protocol for the cross-coupling of (hetero)aryl bromides with fluorinated alcohols using the commercially available precatalyst tBuBrettPhos Pd G3 and Cs2CO3 in toluene. This Pd-catalyzed coupling features a short reaction time, excellent functional group tolerance, and compatibility with electron-rich and-poor (hetero)arenes. The method provides access to 18F-labeled trifluoroethyl ethers by cross-coupling with [18F]trifluoroethanol.

Erratum: Well-Defined Copper(I) Fluoroalkoxide Complexes for Trifluoroethoxylation of Aryl and Heteroaryl Bromides (Angewandte Chemie - International Edition (2015) (54) DOI: 10.1002/anie.201501257)

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