62158-89-8

Basic information

• Product Name: 4-(2,2,2-TRIFLUOROETHOXY)TOLUENE
• Synonyms: 4-(2,2,2-TRIFLUOROETHOXY)TOLUENE
• CAS NO: 62158-89-8
• Molecular Formula: C₉H₉F₃O
• Molecular Weight: 190.16
• Mol File: 62158-89-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 178.6°C at 760 mmHg
• Flash Point: 68.1°C
• Appearance: /
• Density: 1.169g/cm³
• Vapor Pressure: 1.33mmHg at 25°C
• Refractive Index: 1.439
• CAS DataBase Reference: 4-(2,2,2-TRIFLUOROETHOXY)TOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,2,2-TRIFLUOROETHOXY)TOLUENE(62158-89-8)
• EPA Substance Registry System: 4-(2,2,2-TRIFLUOROETHOXY)TOLUENE(62158-89-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 62158-89-8(Hazardous Substances Data)

Usage

General Description

4-(2,2,2-TRIFLUOROETHOXY)TOLUENE is a chemical compound consisting of a toluene molecule with a trifluoroethoxy group attached to one of its carbon atoms. The trifluoroethoxy group consists of three fluorine atoms attached to an ethoxy group, which in turn is attached to the toluene molecule. 4-(2,2,2-TRIFLUOROETHOXY)TOLUENE is used as a reagent in organic synthesis, and its trifluoroethoxy group makes it useful for introducing fluorine atoms into organic molecules. It is commonly used in pharmaceutical and agrochemical industries for the synthesis of new compounds and has potential applications in research and development. Additionally, it may also be used as a solvent in certain chemical processes due to its unique chemical properties.

InChI:InChI=1/C9H9F3O/c1-7-2-4-8(5-3-7)13-6-9(10,11)12/h2-5H,6H2,1H3

Upstream product

• 106-44-5 p-cresol 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 75-89-8 2,2,2-trifluoroethanol 
• 624-31-7 4-tolyl iodide 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 123726-16-9 bis(4-methylphenyl)iodonium trifluoromethanesulfonate 

Downstream Products

• 69393-83-5 1-(hex-1-yn-1-yloxy)-4-methylbenzene 
• 69393-84-6 1-Methyl-4-(3-methyl-pent-1-ynyloxy)-benzene 
• 69393-85-7 1-Hept-1-ynyloxy-4-methyl-benzene 
• 126300-83-2 4-trifluoroethoxybenzyl bromide 
• 126300-92-3 2-Amino-3-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-propionic acid 
• 126300-88-7 2-Formylamino-2-[4-(2,2,2-trifluoro-ethoxy)-benzyl]-malonic acid diethyl ester 

Relevant articles and documents

A product analytical study of the thermal and photolytic decomposition of some arenediazonium salts in solution

Products of thermal and photochemical reactions of eleven arenediazonium tetrafluoroborates in various solvents have been analyzed. All compounds in most solvents undergo unimolecular heterolysis to give singlet aryl cations which are captured by solvent. This mechanism is dominant for arenediazonium ions without electron-withdrawing substituents in all solvents, and the only reaction observed in water. Additionally, appreciable yields of fluoroarenes are obtained by fluoride abstraction by the aryl cation from fluorinated solvents and from tetrafluoroborate in fluorinated solvents. Yields from photochemical processes are very similar to those from thermal reactions indicating that the main reactions proceed through common or very similar intermediates. Aryl cations formed from ion-paired diazonium ions may react with the counterion, but fragmentation of dissociated diazonium ions leads only to solvent-derived product. Some arenediazonium ions in some solvents undergo an alternative radical reaction leading principally to hydrodediazoniation. It is proposed that this reaction involves initial rate-limiting electron transfer from ethanol to the arenediazonium ion followed rapidly by homolysis of the resultant aryldiazenyl radical. Within the same solvent cage, the aryl radical then either abstracts an α-hydrogen from the ethanol radical cation generated in the first step to give the reduction product and protonated acetaldehyde, or combines with it at the oxygen to give a protonated aryl ethyl ether.

Copper(I)-Assisted Synthesis of Aryl 2,2,2-Trifluoroethyl Ethers

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