621685-54-9

Basic information

• Product Name: Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 6-(hydroxymethyl)-5-methyl- (9CI)
• Synonyms: Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 6-(hydroxymethyl)-5-methyl- (9CI);6-(hydroxyMethyl)-5-Methylpyrrolo[1,2-f][1,2,4]triazin-4(1H)-one
• CAS NO: 621685-54-9
• Molecular Formula: C₈H₉N₃O₂
• Molecular Weight: 179.178
• Product Categories: PYRROLE
• Mol File: 621685-54-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 6-(hydroxymethyl)-5-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 6-(hydroxymethyl)-5-methyl- (9CI)(621685-54-9)
• EPA Substance Registry System: Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 6-(hydroxymethyl)-5-methyl- (9CI)(621685-54-9)

Safety Data

• Hazardous Substances Data: 621685-54-9(Hazardous Substances Data)

Upstream product

• 427878-70-4 ethyl 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 427878-70-4 ethyl 4-hydroxy-5-methylpyrrolo[2,1-f ][1,2,4]-triazine-6-carboxylate 

Downstream Products

• 621685-55-0 C₈H₇N₃O₂ 
• 623152-50-1 C₂₄H₂₁N₅O₄ 
• 623152-49-8 C₃₂H₂₉FN₆O₃ 
• 621685-42-5 C₂₄H₂₃N₅O₃ 
• 621685-41-4 C₂₅H₂₅N₅O₃ 
• 621685-48-1 C₂₄H₂₃N₅O₂ 
• 621685-51-6 C₂₄H₂₃N₅O₃ 
• 621685-40-3 C₂₄H₂₃N₅O₃ 
• 621685-50-5 C₂₄H₂₃N₅O₃ 
• 621685-52-7 C₂₃H₂₀FN₅O₂ 
• 621685-49-2 C₂₃H₂₀FN₅O₂ 
• 621685-53-8 C₂₄H₂₁N₅O₄ 
• 621685-47-0 C₂₃H₂₂N₆O₂ 
• 623152-51-2 C₃₂H₂₉FN₆O₃ 

Relevant articles and documents

Commercial synthesis of a pyrrolotriazine-fluoroindole intermediate to brivanib alaninate: Process development directed toward impurity control

The development of a practical, commercial process for the preparation of 4-fluoro-2-methyl-indol-5-ol and its subsequent coupling with a pyrrolotriazine to form an advanced intermediate of the oncology therapy brivanib alaninate is described. A key aspect is the multikilogram-scale preparation of the fluoroindole intermediate from trifluoronitrobenzene and the subsequent coupling while achieving impurity minimalization. As brivanib alaninate is a high-dose drug, the synthesis of highquality API with low levels of impurities is critical.

Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors

Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are surprisingly advantageous as p38 kinase inhibitors, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, NH2