622-52-6Relevant articles and documents
Retinoic acid derivative with multiple target points and preparation method and application thereof
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, (2021/02/24)
The invention provides a retinoic acid derivative with multiple targets and a preparation method and application thereof A series of novel multi-target retinoic acid derivatives are designed and synthesized by taking a multi-target drug theory as guidance, taking Am580 as a parent nucleus and combining structural characteristics of Am580 to select N-hydroxyguanidine NO donors as NO sources, performing chemical modification on the NO donors to obtain a series of different donors, and coupling ester or amido bonds with the parent nucleus. Experiments prove that the derivative has the characteristics of higher activity, lower toxic and side effects and better anti-tumor effect. The structural general formula of the retinoic acid derivative with multiple target points is shown as the followingformula (I),.
Green and efficient synthesis of thioureas, ureas, primary: O -thiocarbamates, and carbamates in deep eutectic solvent/catalyst systems using thiourea and urea
Bagherzadeh, Nastaran,Sardarian, Ali Reza,Inaloo, Iman Dindarloo
supporting information, p. 11852 - 11858 (2021/07/12)
An efficient and general catalysis process was developed for the direct preparation of various primary O-thiocarbamates/carbamates as well as monosubstituted thioureas/ureas by using thiourea/urea as biocompatible thiocarbonyl (carbonyl) sources. This procedure used choline chloride/tin(ii) chloride [ChCl][SnCl2]2 with a dual role as a green catalyst and reaction medium to afford the desired products in moderate to excellent yields. Moreover, the DES can be easily recovered and reused for seven cycles with no significant loss in its activity. Besides, the method shows very good performance for synthesizing the desired products on a large scale.
Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds
Benhida, Rachid,Demange, Luc,Dufies, Maeva,Grytsai, Oleksandr,Hagege, Anais,Martial, Sonia,Pagès, Gilles,Penco-Campillo, Manon,Ronco, Cyril,Valiashko, Oksana
, (2020/10/02)
Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.