62214-31-7

Basic information

• Product Name: 1-BENZOYL-2-(FURFURYLIDENE)HYDRAZINE
• CAS NO: 62214-31-7
• Molecular Formula: C₁₂H₁₀N₂O₂
• Molecular Weight: 214.224
• Mol File: 62214-31-7.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 1-BENZOYL-2-(FURFURYLIDENE)HYDRAZINE (CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZOYL-2-(FURFURYLIDENE)HYDRAZINE (62214-31-7)
• EPA Substance Registry System: 1-BENZOYL-2-(FURFURYLIDENE)HYDRAZINE (62214-31-7)

Safety Data

• Safety Statements: Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NOsub xmlns="">x/sub>.
• Hazardous Substances Data: 62214-31-7(Hazardous Substances Data)

Usage

General Description

1-BENZOYL-2-(FURFURYLIDENE)HYDRAZINE is a chemical compound with the molecular formula C14H12N2O2. It is an organic hydrazine derivative that contains both a benzoyl and furfurylidene group. 1-BENZOYL-2-(FURFURYLIDENE)HYDRAZINE is commonly used in organic synthesis and medicinal chemistry as a versatile building block for the construction of various heterocyclic compounds. It has shown potential in its ability to inhibit the growth of cancer cells and has also been studied for its potential as an antitubercular agent. Additionally, it has been investigated for its antimicrobial and antioxidant properties, making it a versatile and valuable compound in the field of pharmaceuticals and chemical research.

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 65-85-0 benzoic acid 
• 98-01-1 furfural 
• 613-94-5 benzoic acid hydrazide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1366284-37-8 N-(2,2-difluoro-1-(furan-2-yl)-3-oxo-3-phenylpropyl)benzohydrazide 
• 1448781-83-6 ((3S,3aS,6aS)-3-(furan-2-yl)-2,3,3a,4-tetrahydrocyclopenta[c]pyrazol-1(6aH)-yl)(phenyl)methanone 
• 1259388-11-8 N'-(2,2-difluoro-1-(furan-2-yl)-3-oxo-3-phenylpropyl)benzohydrazide 
• 1242282-91-2 diethyl 2-[(E)-1-benzoyl-2-(furan-2-ylmethylene)hydrazinyl]fumarate 
• 14093-97-1 2-(furan-2-yl)-5-phenyl-1,3,4-oxadiazole 
• 1036405-51-2 RuCl₂(dimethylsulfoxide)2(benzoic acid furan-2-ylmethylenehydrazide) 
• 915962-30-0 [RuCl₂(triphenylphosphine)2(C₄H₃OCHNNCOC₆H₅)] 
• 240496-41-7 Co(C₄H₃OCHN₂HCO(C₆H₅))2Cl₂ 

Relevant articles and documents

Synthesis and spectral characterization of hydrazone derivative of furfural using experimental and DFT methods

The Spectral Characterization of (E)-1-(Furan-2-yl) methylene)-2-(1- phenylvinyl) hydrazine (FMPVH) were carried out by using FT-IR, FT-Raman and UV-Vis., Spectrometry. The B3LYP/6-311++G(d, p) level of optimization has been performed on the title compoun

Modulation of estrogen-related receptors subtype selectivity: Conversion of an ERRβ/γ selective agonist to ERRα/β/γ pan agonists

Estrogen Related Receptors (ERRs) are key regulators of energy homeostasis and play important role in the etiology of metabolic disorders, skeletal muscle related disorders, and neurodegenerative diseases. Among the three ERR isoforms, ERRα emerged as a potential drug target for metabolic and neurodegenerative diseases. Although ERRβ/γ selective agonist chemical tools have been identified, there are no chemical tools that effectively target ERRα agonism. We successfully engineered high affinity ERRα agonism into a chemical scaffold that displays selective ERRβ/γ agonist activity (GSK4716), providing novel ERRα/β/γ pan agonists that can be used as tools to probe the physiological roles of these nuclear receptors. We identified the structural requirements to enhance selectivity toward ERRα. Molecular modeling shows that our novel modulators have favorable binding modes in the LBP of ERRα and can induce conformational changes where Phe328 that originally occupies the pocket is dislocated to accommodate the ligands in a rather small cavity. The best agonists up-regulated the expression of target genes PGC-1α and PGC-1β, which are necessary to achieve maximal mitochondrial biogenesis. Moreover, they increased the mRNA levels of PDK4, which play an important role in energy homeostasis.

METHOD FOR PREPAREING 1,3,4-OXADIAZOL UNDER SOLVENT-FREE CONDITION

The present invention relates to a synthesis method of 1,3,4-oxadiazol, comprising: 1) under a solvent-free condition and by means of a mechanical pulverization method, making a hydrazide compound react with an aldehyde compound and thereby synthesizing a N-acylhydrazone compound; and 2) under a solvent-free condition, adding an iodine-based oxidizing agent to the N-acylhydrazone compound to synthesize 1,3,4-oxadiazol via oxidative cyclization. The solventless synthesis method of 1,3,4-oxadiazol according to the present invention is easy to perform and handle, and has the advantage of synthesizing 1,3,4-oxadiazol at high selectivity and yield. Also, the solventless synthesis method of the present invention can prevent the formation of side products caused by the minute amount of water that usually remains in solvents, and can further prevent synthesized intermediates from being converted back into the starting materials by the water.COPYRIGHT KIPO 2016