62245-12-9

Basic information

• Product Name: 6-acetyl-1,2,3,4-tetrahydroquinolin-2-one
• Synonyms: 6-acetyl-1,2,3,4-tetrahydroquinolin-2-one;6-ACETYL-3,4-DIHYDRO-2(1H)-QUINOLINONE;6-Acetyl-3,4-dihydroquinolin-2(1H)-one
• CAS NO: 62245-12-9
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.213
• Mol File: 62245-12-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 161.0-162.0 °C
• Boiling Point: 429.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.180±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.20±0.20(Predicted)
• CAS DataBase Reference: 6-acetyl-1,2,3,4-tetrahydroquinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-acetyl-1,2,3,4-tetrahydroquinolin-2-one(62245-12-9)
• EPA Substance Registry System: 6-acetyl-1,2,3,4-tetrahydroquinolin-2-one(62245-12-9)

Safety Data

• Hazardous Substances Data: 62245-12-9(Hazardous Substances Data)

Upstream product

• 553-03-7 3,4-dihydro-2(1H)-quinolone 
• 75-36-5 acetyl chloride 
• 746622-09-3 3-(2-amino-5-acetylphenyl)-1-propanol 
• 19718-49-1 4-amino-3-iodobenzoic acid methyl ester 
• 833486-28-5 3-(2-amino-5-methoxycarbonylphenyl)-2-propyn-1-ol 

Relevant articles and documents

Synthesis of five-, six-, and seven-membered ring lactams by Cp*Rh complex-catalyzed oxidative N-heterocyclization of amino alcohols

A new effective catalytic system consisting of [Cp*RhCl 2]2/K2CO3 (Cp* = pentamethylcyclopentadienyl) for the lactamization of amino alcohols has been developed. As an example, the reaction of 3-(2-aminophenyl)-1-propanol in the presence of [Cp*RhCl2]2 (5.0% Rh) and K 2CO3 (10%) in acetone gives 3,4-dihydro-2(1H)-quinolinone in an isolated yield of 80%. A variety of five-, six-, and seven-membered benzo-fused lactams are synthesized by this catalytic system.

Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors

The invention concerns a method of inhibiting both thromboxane synthetase and cyclic-AMP phosphodiesterase in a mammal having a disease characterized by elevated thromboxane levels or an imbalance of prostacyclin/thromboxane levels with a compound of the