62250-12-8Relevant articles and documents
Inhibition of Pancreatic α-amylase by Resveratrol Derivatives: Biological activity and molecular modelling evidence for cooperativity between viniferin enantiomers
Mattio, Luce M.,Marengo, Mauro,Parravicini, Chiara,Eberini, Ivano,Dallavalle, Sabrina,Bonomi, Francesco,Iametti, Stefania,Pinto, Andrea
supporting information, (2019/09/09)
To improve the current understanding of the role of stilbenoids in the management of diabetes, the inhibition of the pancreatic α-amylase by resveratrol derivatives was investigated. To approach in a systematic way, the mechanistic and structural aspects of the interaction, potential bioactive agents were prepared as single molecules, that were used for the biological evaluation of the determinants of inhibitory binding. Some dimeric stilbenoids—in particular, viniferin isomers— were found to be better than the reference drug acarbose in inhibiting the pancreatic α-amylase. Racemic mixtures of viniferins were more effective inhibitors than the respective isolated pure enantiomers at an equivalent total concentration, and displayed cooperative effects not observed with the individual enantiomers. The molecular docking analysis provided a thermodynamics-based rationale for the measured inhibitory ability and for the observed synergistic effects. Indeed, the binding of additional ligands on the surface of the alpha-amylase was found to decrease the dissociation constant of inhibitors bound to the active site of the enzyme, thus providing a mechanistic rationale for the observed inhibitory synergies.
Applications of Amurensin H derivatives in treating and prevention liver related diseases
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Paragraph 0116-0121, (2019/11/20)
The invention discloses applications of Amurensin H derivatives shown as a formula (I) and (II) and pharmaceutically acceptable salt thereof in the preparation of drugs for treating and/or preventingliver related diseases, and also discloses the preparation method of a compound, and applications of the pharmaceutical composition of the compound in the preparation of the drugs for treating and/orpreventing the liver related diseases.
A joint experimental and theoretical investigation on the oxidative coupling of resveratrol induced by copper and iron ions
Tamboli, Vajir F.,Re, Nazzareno,Coletti, Cecilia,Defant, Andrea,Mancini, Ines,Tosi, Paolo
body text, p. 55 - 63 (2012/08/28)
Currently, a mounting interest exists on the biological activity of polyphenolic compounds, which have been suggested to exert positive effects on the human health. In this paper we report the first electrospray ionization mass spectrometry (ESI-MS) study on the gas-phase production of isomeric δ-viniferin and ε-viniferin dimers in racemic form, starting from acetonitrile/water solutions containing resveratrol and CuSO4 or FeCl3, respectively. Interestingly, the formation of racemic δ-viniferin dehydrodimer is observed in ESI-MS experiments carried out on resveratrol-copper mixtures, while the analogous resveratrol-iron reaction affords the racemic ε-viniferin dehydrodimer. The use of gas-phase techniques and of ab initio calculations, at BHandHLYP/LACV3P + +** level of theory, allowed us to elucidate some important aspects of these reaction mechanisms. In particular, a different stability for the resveratrol radicals involved in the oxidative coupling has been obtained in the presence of copper ion, favoring the formation of δ-viniferin, as proposed for the in vivo mechanism where copper is able to switch the resveratrol from an antioxidant to a prooxidant agent. Finally, the structure-reactivity relationship has been investigated for synthetic analogues of resveratrol, showing the crucial role of the OH group in para position.
