62260-39-3

Basic information

• Product Name: 4-HYDROXY-2-METHYL-6-PHENYLPYRIMIDINE
• Synonyms: 4-HYDROXY-2-METHYL-6-PHENYLPYRIMIDINE;BUTTPARK 13\01-49;2-Methyl-6-phenylpyrimidin-4-ol;4-Hydroxy-2-methyl-6-phenylpyrimidine, 4-Hydroxy-2-methyl-6-phenyl-1,3-diazine
• CAS NO: 62260-39-3
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.21
• Mol File: 62260-39-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 330.2°C at 760 mmHg
• Flash Point: 153.5°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.000169mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: 4-HYDROXY-2-METHYL-6-PHENYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-2-METHYL-6-PHENYLPYRIMIDINE(62260-39-3)
• EPA Substance Registry System: 4-HYDROXY-2-METHYL-6-PHENYLPYRIMIDINE(62260-39-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 62260-39-3(Hazardous Substances Data)

Usage

General Description

4-HYDROXY-2-METHYL-6-PHENYLPYRIMIDINE is a chemical compound with the molecular formula C11H10N2O. It is a pyrimidine derivative with a hydroxyl group and a methyl group attached to the 2 and 4 positions, respectively, of the pyrimidine ring, and a phenyl group attached to the 6 position. 4-HYDROXY-2-METHYL-6-PHENYLPYRIMIDINE has potential applications in pharmaceuticals and organic synthesis as it possesses interesting biological and pharmacological properties. It can be used as a building block for the synthesis of various pharmaceuticals and organic compounds, making it a valuable chemical in the field of medicinal chemistry and drug development.

InChI:InChI=1/C11H10N2O/c1-8-12-10(7-11(14)13-8)9-5-3-2-4-6-9/h2-7H,1H3,(H,12,13,14)

Upstream product

• 31301-40-3 N-(3-phenyl-1,2-oxazol-5-yl)acetamide 
• 124-42-5 acetamidine hydrochloride 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 2915-15-3 4-chloro-2-methyl-6-phenyl-pyrimidine 
• 497944-94-2 4-isopropoxy-2-methyl-6-phenyl-pyrimidine 
• 62459-17-0 2-benzylsulfanyl-6-phenyl-3H-pyrimidin-4-one 
• 497944-64-6 2-benzylsulfanyl-4-isopropoxy-6-phenyl-pyrimidine 
• 497944-67-9 4-isopropoxy-6-phenyl-2-phenylmethanesulfonyl-pyrimidine 
• 36822-11-4 2-mercapto-6-phenylpyrimidin-4(3H)-one 
• 98-86-2 acetophenone 
• 2021-28-5 ethyl dihydrocinnamate 
• 17551-52-9 2-methyl-4-hydroxy-6-chloropyrimidine 
• 98-80-6 phenylboronic acid 
• 1780-26-3 2,4-dichloro-2-methylpyrimidine 

Downstream Products

• 92289-38-8 4-amino-2-methyl-6-phenylpyrimidine 
• 2915-15-3 4-chloro-2-methyl-6-phenyl-pyrimidine 
• 128266-65-9 5-bromo-2-methyl-4-phenyl-6(1H)-pyrimidinone 
• 86421-66-1 2,3-dimethyl-6-phenyl-4(3H)-pyrimidinone 
• 150651-46-0 2,2'-dimethyl-6,6'-diphenyl-4,4'-bipyrimidine 
• 151373-24-9 2-Bromomethyl-2'-methyl-6,6'-diphenyl-[4,4']bipyrimidinyl 
• 128266-66-0 5-bromo-4-chloro-2-methyl-6-phenyl-pyrimidine 
• 128266-68-2 N-(5-bromo-2-methyl-6-phenyl-4-pyrimidinyl)methanesulfonamide 
• 128266-72-8 7-Methanesulfonyl-2-methyl-4-phenyl-6-trimethylsilanyl-7H-pyrrolo[2,3-d]pyrimidine 
• 128266-75-1 6-Butyl-7-methanesulfonyl-2-methyl-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine 

Relevant articles and documents

Discovery of wtRET and V804MRET Inhibitors: From Hit to Lead

Oncogenic activation of RET kinase has been found in several neoplastic diseases, like medullary thyroid carcinoma, multiple endocrine neoplasia, papillary thyroid carcinoma, and non-small-cell lung cancer. Currently approved RET inhibitors were not originally designed to be RET inhibitors, and their potency against RET kinase has not been optimized. Hence, novel compounds able to inhibit both wild-type RET (wtRET) and its mutants (e.g., V804MRET) are needed. Herein we present the development and the preliminary evaluation of a new sub-micromolar wtRET/V804MRET inhibitor, N-(2-fluoro-5-trifluoromethylphenyl)-N′-{4′-[(2′′-benzamido)pyridin-4′′-ylamino]phenyl}urea (69), endowed with a 4-anilinopyridine structure, starting from our previously identified 4-anilinopyrimidine hit compound. Profiling against a panel of kinases indicated 69 as a multi cKIT/wtRET/V804MRET inhibitor.

A facile synthesis of pyrimidin-4-ones

A facile synthesis of 2,6-disubstituted pyrimidin-4-ones and 2,5,6-trisubstituted pyrimidin-4-ones from commercially available materials with application of microwave technology in key steps is described.

PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF

Disclosed are compounds of Formula I effective as cytotoxic agents. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.