622785-69-7

Basic information

• Product Name: 2'-Deoxy-2'-fluoro-L-uridine
• Synonyms: 2'-Deoxy-2'-fluoro-L-uridine;1-(2-Deoxy-2-fluoro-beta-L-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione
• CAS NO: 622785-69-7
• Molecular Formula: C₉H₁₁FN₂O₅
• Molecular Weight: 246.1924432
• Mol File: 622785-69-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.63±0.1 g/cm3(Predicted)
• PKA: 9.39±0.10(Predicted)
• CAS DataBase Reference: 2'-Deoxy-2'-fluoro-L-uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Deoxy-2'-fluoro-L-uridine(622785-69-7)
• EPA Substance Registry System: 2'-Deoxy-2'-fluoro-L-uridine(622785-69-7)

Safety Data

• Hazardous Substances Data: 622785-69-7(Hazardous Substances Data)

Upstream product

• 323193-78-8 2'-deoxy-2'-fluoro-3',5'-di-O-tetrahydropyranyl-β-L-uridine 
• 288325-70-2 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-L-ribofuranosyl)uracil 
• 288325-69-9 1-[(2S,3R,4R,5S)-3-Hydroxy-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione 
• 31501-46-9 (2S,3S,3aR,9aS)-3-hydroxy-2-(hydroxymethyl)-2,3,3a,9a-tetrahydro-6H-furo[2,3’:4,5]oxazolo[3,2-a]pyrimidin-6-one 
• 849342-74-1 L-2,2'-anhydro-3',5'-di-O-tetrahydropyranyluridine 
• 87-72-9 L-(+)-arabinose 
• 922-67-8 propynoic acid methyl ester 
• 532-20-7 L-arabinose 
• 103763-12-8 5-O-tert-butyldiphenylsilyl-α,β-L-arabinofuranose 
• 103763-14-0 (3aR,5S,6S,6aR)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxol-6-ol 
• 51885-64-4 1,2-O-isopropylidene-β-L-arabinofuranose 
• 190583-85-8 1,2-O-isopropylidene-3,5-di-O-benzyl-β-L-arabinofuranose 
• 339091-38-2 methyl 3,5-di-O-benzyl-L-arabinofuranoside 
• 442514-57-0 1-O-methyl-2-deoxy-2-fluoro-L-arabinofuranoside 

Downstream Products

• 146954-74-7 2'-deoxy-2'-fluoro-5'-O-(4,4'-dimethoxytrityl)uridine 

Relevant articles and documents

Synthesis and Structural Characterization of 2′-Deoxy-2′-fluoro-l-uridine Nucleic Acids

Despite the development of artificial l-RNA/DNA as therapeutic molecules, the in-depth investigation on their chemical modifications is still limited. Here, we synthesize a chemically derivatized 2′-deoxy-2′-fluoro-l-uridine building block and incorporate

MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF

The present disclosure provides oligomeric compounds comprising a modified oligonucleotide having at least one stereo-non-standard nucleoside. An oligomeric compound comprising a modified oligonucleotide consisting of 12-30 linked nucleosides, wherein at least one nucleoside of the modified oligonucleotide is a stereo-non-standard nucleoside; and wherein the oligomeric compound is selected from among an RNAi compound, a modified CRISPR compound, and an artificial mRNA compound.

NOVEL 3′-DEOXY-3′-METHYLIDENE- -L-NUCLEOSIDES

The present invention includes novel 3′-deoxy-3′-methylidene-β-L-nucleosides, pharmaceutical composition comprising such compounds, as well as the methods to treat or to prevent viral infections and in particular HBV and/or HIV infections. In accordance with the present invention, there are provided compounds represented by Formula (I), wherein B is selected from A1 and A2;