623113-98-4

Basic information

• Product Name: 1,8-Naphthyridine-3-carboxylic acid, 2-(2-benzoylhydrazino)-, ethyl ester
• CAS NO: 623113-98-4
• Molecular Formula: C18H16N4O3
• Molecular Weight: 336.35
• Mol File: 623113-98-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,8-Naphthyridine-3-carboxylic acid, 2-(2-benzoylhydrazino)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-Naphthyridine-3-carboxylic acid, 2-(2-benzoylhydrazino)-, ethyl ester(623113-98-4)
• EPA Substance Registry System: 1,8-Naphthyridine-3-carboxylic acid, 2-(2-benzoylhydrazino)-, ethyl ester(623113-98-4)

Safety Data

• Hazardous Substances Data: 623113-98-4(Hazardous Substances Data)

Upstream product

• 5174-90-3 1,8-naphthyridin-2(1H)-on-3-carboxylic acid ethyl ester 
• 613-94-5 benzoic acid hydrazide 
• 132209-79-1 ethyl 2-chloro-1,8-naphthyridine-3-carboxylate 

Relevant articles and documents

Synthesis of some novel azetidino[2,3-b][1,8]naphthyridin-2(1H)-ones and 1,2,4-triazolo [4,3-a][1,8] naphthyridines

Ethyl 1.8-naphthyridin-2-one-3-carboxylate 1 on fusion with different anilines at 200°C affords N-aryl-1,8-naphthyridin-2-one-3-carboxamides 2, which undergo smooth cyclization with POCl3 yielding 1-arylazetidino [2,3-b][1,8]naphthyridin-2(1H)-ones 3. Compound 1 on treatment with POCl 3 yield ethyl 2-chloro-1,8-naphthyridine-3-carboxylate 4, which on reaction with aromatic acid hydrazides in methanol furnishes respective N-aroyl-N'-(3-carbethoxy-1,8-naphthyridin-2-yl) hydrazines 5. Cyclization of 5 with POCl3 under reflux result in the formation of 1-aryl-4-carbethoxy-1,2,4-triazol [4,3-a][1,8]naphthyridines 6. Compounds 3 and 6 have been evaluated for their antibacterial activity using streptomycin as a reference compound.