6232-35-5

Basic information

• Product Name: 6H-Pyrano[3,2-b]acridin-6-one,2,11-dihydro- 5-methoxy-2,2,11-trimethyl-
• Synonyms: Acromycin;5-Methoxy-2,2,11-trimethyl-2,11-dihydro-1-oxa-11-aza-naphthacen-6-one;2,11-Dihydro-5-methoxy-2,2,11-trimethyl-2H,6H-pyrano<2,3-c>acridin-6-on;Acronycin;5-methoxy-2,2,11-trimethyl-2,11-dihydro-pyrano[3,2-b]acridin-6-one;5-Methoxy-2,2,11-trimethyl-2H-pyrano<2,3-b>acridan-6-on
• CAS NO: 6232-35-5
• Molecular Formula: C20H19NO3
• Molecular Weight: 321.376
• Mol File: 6232-35-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6H-Pyrano[3,2-b]acridin-6-one,2,11-dihydro- 5-methoxy-2,2,11-trimethyl- (CAS DataBase Reference)
• NIST Chemistry Reference: 6H-Pyrano[3,2-b]acridin-6-one,2,11-dihydro- 5-methoxy-2,2,11-trimethyl- (6232-35-5)
• EPA Substance Registry System: 6H-Pyrano[3,2-b]acridin-6-one,2,11-dihydro- 5-methoxy-2,2,11-trimethyl- (6232-35-5)

Safety Data

• Hazardous Substances Data: 6232-35-5(Hazardous Substances Data)

Upstream product

• 79228-40-3 6-(2-N-methylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene 
• 31525-67-4 dimethylacetal of 3-methyl-3-hydroxybutyraldehyde 
• 20324-10-1 1,3-dihydroxyacridin-9(10H)-one 

Relevant articles and documents

RUTACEOUS CONSTITUENTS-13 A BIOMIMETIC SYNTHESIS OF ACRONYCINE

A biomimetic synthesis of the anti-tumor active alkaloid acronycine (7; R=R'=Me) has been obtained by cyclisation of 6-(2-methylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene (11; R=R'=Me); isoacronycine (20; R=R'=Me) was also produced.In an analogous manner the aminochromene (11; R=H, R'=Me) gave a mixture of des-N-methylacronycine (7; R=H, R'=Me) and des-N-methylisoacronycine (20; R=H, R'=Me).The aminochromenes were best synthesised by condensation of lithio-5,7-dimethoxy-2,2-dimethylchromene (22; R=Li) with N-methylisatoic anhydride (26) or with 2-methyl-3,1-benzoxazin-4-one (21).The relevance of this synthetic route to the biogenesis of acridone alkaloids is discussed.