62381-20-8

Basic information

• Product Name: 2-(3-methylphenyl)-1,3-dithiane
• Synonyms: 2-(3-methylphenyl)-1,3-dithiane
• CAS NO: 62381-20-8
• Molecular Formula: C₁₁H₁₄S₂
• Molecular Weight: 210.35886
• Mol File: 62381-20-8.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3-methylphenyl)-1,3-dithiane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-methylphenyl)-1,3-dithiane(62381-20-8)
• EPA Substance Registry System: 2-(3-methylphenyl)-1,3-dithiane(62381-20-8)

Safety Data

• Hazardous Substances Data: 62381-20-8(Hazardous Substances Data)

Upstream product

• 109-80-8 1.3-propanedithiol 
• 620-23-5 m-tolyl aldehyde 
• 57529-04-1 2-chloro-1,3-dithiane 

Downstream Products

• 620-23-5 m-tolyl aldehyde 
• 1243701-43-0 C₁₆H₂₂OS₂ 
• 1622220-01-2 (4-(difluoromethoxy)-3-methylphenyl)(2-(3-methylphenyl)-1,3-dithian-2-yl)methanol 
• 1622220-02-3 2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3-methylphenyl)-2-hydroxyethanone 
• 1062614-17-8 1-(4-(difluoromethoxy)-3-methylphenyl)-2-(3-methylphenyl)ethane-1,2-dione 
• 1065166-57-5 2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one 
• 53039-63-7 (4-methoxyphenyl)(3-methylphenyl)methanone 
• 53039-51-3 1-(4-methoxybenzyl)-3-methylbenzene 
• 68185-95-5 m-tolyl(trimethylsilyl)methanone 

Relevant articles and documents

A 2 - substituted - 1, 3 - dithiane derivative of the preparation method

The invention provides a preparation method of a 2-substituted-1,3-dithiane derivative. The preparation method comprises the following steps: adding 1,3-dithiane (CAS:505-23-7) and 1,2-dichloroethane (DCE) or dichloromethane (DCM) into a reaction bottle, adding N-chlorosuccinimide (NCS) under ice-bath condition, and stirring for 0.5-1 h to prepare a 2-chloro-1,3-dithiane solution; and adding an aldehyde or ketone compound and a lewis acid catalyst into the above solution, and reacting to prepare the 2-substituted-1,3-dithiane derivative. By using the 1,3-dithiane solid and different types of aldehyde and keto-carbonyl compounds as raw material and using one or more of ferric trichloride, boron trifluoride diethyl etherate, methanesulfonic acid, aluminum trichloride, ferrous chloride and nickel chloride as catalysts, preparation of the 2-substituted-1,3-dithiane derivative is realized. The catalysts used in the invention are cheap and easily available, dosage of the catalysts is low and pollution of the catalysts is little. The solid raw materials used in the invention can avoid use of fetid toxic 1,3-dimercaptopropane with strong volatility, and the purpose of protecting an experimenter's body and reducing environmental pollution is realized. In addition, the preparation method has advantages of mild reaction condition, high yield, simple operation and the like.

Oxidative [1,2]-Brook Rearrangements Exploiting Single-Electron Transfer: Photoredox-Catalyzed Alkylations and Arylations

Oxidative [1,2]-Brook rearrangements via hypervalent silicon intermediates induced by photoredox-catalyzed single-electron transfer have been achieved, permitting the formation of reactive radical species that can engage in alkylations and arylations.

HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING

In certain embodiments hydantoin compounds are provided herein that are effective to inhibit BACE activity against APP. Without being bound to a particular theory, it is believed the activity of the hydantoins identified herein appears to be associated wi