62421-32-3

Basic information

• Product Name: Benzenesulfonamide, 4-methyl-N-[1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]butyl]-, (R)-
• CAS NO: 62421-32-3
• Molecular Formula: C19H25NO5S2
• Molecular Weight: 411.543
• Mol File: 62421-32-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-methyl-N-[1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]butyl]-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-methyl-N-[1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]butyl]-, (R)-(62421-32-3)
• EPA Substance Registry System: Benzenesulfonamide, 4-methyl-N-[1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]butyl]-, (R)-(62421-32-3)

Safety Data

• Hazardous Substances Data: 62421-32-3(Hazardous Substances Data)

Upstream product

• 22724-81-8 L-norvalinol 
• 98-59-9 p-toluenesulfonyl chloride 
• 6600-40-4 L-Norvaline 
• 29582-96-5 L-norvaline methyl ester 
• 80696-30-6 (2R)-2-aminopentan-1-ol 
• 2013-12-9 D-norvaline 

Downstream Products

• 101689-07-0 (R)-3,3,3-Trifluoro-2-methoxy-N-((R)-1-methyl-butyl)-2-phenyl-propionamide 
• 101689-07-0 3,3,3-Trifluoro-2-methoxy-N-((R)-1-methyl-butyl)-2-phenyl-propionamide 
• 101689-05-8 (R)-(+)-(1-methylbutyl)amine hydrochloride 
• 189251-20-5 (7S)-7-({2-[(tert-butyl)dimethylsilyloxy]ethyl}(p-tolylsulfonyl)amino)dec-1-ene 
• 312929-13-8 (7S)-7-[(p-tolylsulfonyl)amino]dec-1-ene 
• 147363-82-4 (S)-epilachnene 
• 354583-03-2 (R)-1-(2-benzofuran-2-yl)-2-N-propyl-p-toluenesulfonylaminopentane 
• 354583-02-1 (R)-1-(benzofuran-2-yl)-2-(p-toluenesulfonyl)aminopentane 
• 260550-89-8 R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane 
• 260550-89-8 (S)-1-(benzofuran-2-yl)-2-propylaminopentane 
• 62421-33-4 (R)-N-(p-toluenesulfonyl)-2-propylaziridine 
• 170956-17-9 (S)-1-[(4-methylphenyl)sulfonyl]-2-propylaziridin 
• 304460-21-7 4-Methyl-N-((R)-1-methyl-butyl)-benzenesulfonamide 

Relevant articles and documents

Enantioselective synthesis and absolute configuration of (-)-1-(benzofuran-2-yl)-2-propylaminopentane, ((-)-BPAP), a highly potent and selective catecholaminergic activity enhancer

Enantioselective synthesis and absolute configuration of (-)-1-(benzofuran-2-yl)-2-propylaminopentane ((-)-BPAP), which is a highly potent and selective catecholaminergic activity enhancer (CAE) substance, are described. The synthetic approach consists of the coupling reaction of benzofuran with (R)-N-tosyl-2-propylazirizine or (R)-N-methoxy-N-methylnorvaliamide, followed by appropriate modifications of the resulting coupling products. As the results, (-)-BPAP turned out to have the R configuration, which was finally confirmed by X-ray crystallographic analysis.

SYNTHESIS OF THE RACEMIC FORM OF (Z)-1,17-DIAMINOOCTADEC-9-ENE, AN ALIPHATIC DIAMINE FROM COCCINELLIDAE. DETERMINATION OF THE ABSOLUTE CONFIGURATION OF THE (+)-NATURALLY-OCCURRING ANTIPODE

The total synthesis of the title compound (1) has been achieved.Also reported is the use of lanthanide induced shifts in 1H NMR spectroscopy to assign the absolute configuration of the α-carbon atom in chiral primary α-methylalkylamines.Application of this empirical method to natural (+)-1 shows that it has the R-configuration at C-17.