62457-35-6

Basic information

• Product Name: 3-phthaliMidylpropane-1,2-diol
• Synonyms: 3-phthaliMidylpropane-1,2-diol;Rivaroxaban Impurity 48;2-(2,3-dihydroxypropyl)isoindole-1,3-dione
• CAS NO: 62457-35-6
• Molecular Formula: C₁₁H₁₁NO₄
• Molecular Weight: 221.20934
• EINECS: -0
• Mol File: 62457-35-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 111.5-112.5 °C
• Boiling Point: 457.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.454±0.06 g/cm3(Predicted)
• PKA: 13.65±0.20(Predicted)
• CAS DataBase Reference: 3-phthaliMidylpropane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phthaliMidylpropane-1,2-diol(62457-35-6)
• EPA Substance Registry System: 3-phthaliMidylpropane-1,2-diol(62457-35-6)

Safety Data

• Hazardous Substances Data: 62457-35-6(Hazardous Substances Data)

Usage

Description

3-phthaliMidylpropane-1,2-diol, also known as 1-(3,4,5,6-Tetrahydrophthalimido)-2,3-dihydroxypropane, is an organic compound with a unique structure that features a phthalimide group attached to a propane-1,2-diol moiety. 3-phthaliMidylpropane-1,2-diol possesses a hydroxyl group at both the 1 and 2 positions of the propane chain, which allows for versatile chemical reactions and applications.

Uses

Used in Pharmaceutical Industry:
3-phthaliMidylpropane-1,2-diol is used as a key intermediate in the synthesis of carbapenem compounds, which are a class of β-lactam antibiotics known for their broad-spectrum antibacterial activity. The presence of the phthalimide group and hydroxyl groups in 3-phthaliMidylpropane-1,2-diol enables the formation of carbapenems with improved stability and potency against various bacterial strains, making it a valuable component in the development of new antibiotics to combat drug-resistant infections.

Upstream product

• 85-44-9 phthalic anhydride 
• 616-30-8 3-Amino-1,2-propanediol 
• 136918-14-4 phthalimide 
• 556-52-5 oxiranyl-methanol 
• 40137-25-5 2-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-1H-isoindole-1,3(2H)-dione 
• 1074-82-4 potassium phtalimide 
• 96-24-2 3-monochloro-1,2-propanediol 
• 5428-09-1 3-phthalimido-1-propene 
• 1074-82-4 phthalimide potassium salt 

Downstream Products

• 186348-65-2 2-[(2-phenyl-1,3-dioxolan-4-yl)methyl]-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

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Controlled precipitation polymerization of phthalimidomethyloxirane in cationic isomerization ring-opening manner

The cationic polymerization of phthalimidomethyloxirane (1) with methylaluminum bis-(2,6-di-tert-butyl-4-methylphenoxide) (MAD) afforded polyether (2) or polyacetal (3) depending on temperature. Acetalic linkages in the main chain of 3 were formed via iso

N-[(1,4-DIAZABICYCLO[2.2.2] OCT-2-YL)METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATIONS AND THEIR APPLICATION IN THERAPEUTICS

An optically active isomer or a racemate of a compound of general formula (I) STR1 in which either R 1 represents a methoxy or cyclopropylmethoxy group andR 2 represents a hydrogen, chlorine or bromine atom, orR 1 and R 2 together form, and in this order, a group of formula--O--CH 2--O--,--O--(CH 2) 2--,--O--(CH 2) 2--O--or--O--(CH 2) 3--O--,R 3 represents a hydrogen atom or an amino group, andR 4 represents a hydrogen, chlorine or bromine atom,in the form of a free base or of a pharmaceutically acceptable acid addition salt.