62482-26-2

Basic information

• Product Name: methyl 2-chloroquinoline-4-carboxylate(SALTDATA: FREE)
• Synonyms: methyl 2-chloroquinoline-4-carboxylate(SALTDATA: FREE);4-Quinolinecarboxylic acid, 2-chloro-, Methyl ester;2-Chloro-quinoline-4-carboxylic acid methyl ester
• CAS NO: 62482-26-2
• Molecular Formula: C₁₁H₈ClNO₂
• Molecular Weight: 221.63972
• Mol File: 62482-26-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: methyl 2-chloroquinoline-4-carboxylate(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-chloroquinoline-4-carboxylate(SALTDATA: FREE)(62482-26-2)
• EPA Substance Registry System: methyl 2-chloroquinoline-4-carboxylate(SALTDATA: FREE)(62482-26-2)

Safety Data

• Hazardous Substances Data: 62482-26-2(Hazardous Substances Data)

Usage

General Description

Methyl 2-chloroquinoline-4-carboxylate is a chemical compound that belongs to the class of quinoline derivatives. It is a white to light yellow crystalline powder that is soluble in organic solvents. methyl 2-chloroquinoline-4-carboxylate(SALTDATA: FREE) has various industrial applications, including its use as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of dyes, pigments, and other fine chemicals. Methyl 2-chloroquinoline-4-carboxylate is considerd as a hazardous substance and should be handled with care, following proper safety measures and guidelines.

Upstream product

• 67-56-1 methanol 
• 39497-01-3 methyl 1,2-dihydro-2-oxoquinoline-4-carboxylate 
• 5467-57-2 2-chloroquinoline-4-carboxylic acid 
• 15733-89-8 2-quinolone-4-carboxylic acid 
• 74-88-4 methyl iodide 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 5471-28-3 Methyl 2-aminoquinoline-4-carboxylate 

Relevant articles and documents

Quinoline substituted chalcone compound as well as preparation method and application thereof

The invention discloses a novel quinoline substituted chalcone compound as well as pharmaceutically acceptable salts and a preparation method thereof. The invention further discloses a pharmaceuticalcomposition which comprises a therapeutically effective amount of the novel quinoline substituted chalcone compound and/or the pharmaceutically acceptable salts and a pharmaceutically acceptable carrier. The invention further discloses a tubulin inhibitor which comprises the novel quinoline substituted chalcone compound and/or the pharmaceutically acceptable salts. The invention further disclosesapplication of the novel quinoline substituted chalcone compound and/or the pharmaceutically acceptable salts in preparing drugs for treating but not limited to colon cancer, leukemia, liver cancer, breast cancer and other diseases. The compound in the application shows excellent anti-tumor activity, and has more stable metabolic properties and better druggability prospect.

A novel method for heterocyclic amide-thioamide transformations

In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61°C to afford heteocyclic thioamides in excellent yields.

Synthesis of the pentacyclic core of lihouidine

The pentacyclic base of the sponge-derived alkaloid lihouidine has been assembled from two quinoline fragments. The key step is a nitration-promoted cyclization to form the C-C bond between the two quinoline units.