62482-45-5

Basic information

• Product Name: 3'-CHLORO-2-PHENYLACETOPHENONE
• Synonyms: 3'-CHLORO-2-PHENYLACETOPHENONE
• CAS NO: 62482-45-5
• Molecular Formula: C₁₄H₁₁ClO
• Molecular Weight: 230.69
• Mol File: 62482-45-5.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 363.8°C at 760 mmHg
• Flash Point: 197.1°C
• Appearance: /
• Density: 1.191g/cm³
• Vapor Pressure: 1.76E-05mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 3'-CHLORO-2-PHENYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-CHLORO-2-PHENYLACETOPHENONE(62482-45-5)
• EPA Substance Registry System: 3'-CHLORO-2-PHENYLACETOPHENONE(62482-45-5)

Safety Data

• Hazardous Substances Data: 62482-45-5(Hazardous Substances Data)

Usage

General Description

3'-Chloro-2-phenylacetophenone is a chemical compound with the molecular formula C14H11ClO. It is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. 3'-CHLORO-2-PHENYLACETOPHENONE is a pale yellow solid with a strong aromatic odor. Its chemical structure consists of a chloro substituent at the 3' position and a phenyl group attached to the carbonyl carbon. 3'-Chloro-2-phenylacetophenone has the potential to be irritating to the skin, eyes, and respiratory system, and should be handled with care in a laboratory or industrial setting.

InChI:InChI=1/C14H11ClO/c15-13-8-4-7-12(10-13)14(16)9-11-5-2-1-3-6-11/h1-8,10H,9H2

Upstream product

• 618-48-4 3-chlorobenzamide 
• 6921-34-2 benzylmagnesium chloride 
• 766-84-7 3-chloro-benzonitrile 
• 72867-64-2 N-[1-(3-Chloro-phenyl)-1-cyano-2-phenyl-ethyl]-N-phenyl-benzamide 
• 95607-25-3 2-(3-Chloro-phenyl)-2-methoxy-1-phenyl-ethanol 
• 145959-21-3 3-chloro-N-methoxy-N-methylbenzamide 
• 95607-23-1 2-[2-(3-Chloro-phenyl)-2-methoxy-1-phenyl-ethoxy]-tetrahydro-pyran 
• 95606-86-3 1-(3-Chloro-phenyl)-2-phenyl-2-(tetrahydro-pyran-2-yloxy)-ethanol 
• 72867-29-9 2-(3-chlorophenyl)-2-(phenylamino) acetonitrile 
• 587-04-2 m-Chlorobenzaldehyde 
• 100-39-0 benzyl bromide 
• 72867-38-0 N-[(3-Chloro-phenyl)-cyano-methyl]-N-phenyl-benzamide 
• 4039-32-1 lithium hexamethyldisilazane 
• 33756-91-1 tris(3-chlorophenyl)bismuthane 

Downstream Products

• 181697-29-0 1-(3-chlorophenyl)-2-phenyl-ethan-1-one oxime 
• 7498-72-8 1-(3-chlorophenyl)-2-phenylethane-1,2-dione 
• 1384131-20-7 (Z)-1-t-butyldimethylsilyloxy-1-(3-chlorophenyl)-2-phenylethene 
• 1283117-46-3 6-(3-chlorophenyl)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 181696-19-5 4-[3-(3-chlorophenyl)-5-methylisoxazol-4-yl]benzenesulfonamide 

Relevant articles and documents

Visible-Light-Promoted [3 + 2] Cycloaddition of 2H-Azirines with Quinones: Access to Substituted Benzo[f]isoindole-4,9-diones

A visible-light-promoteded [3 + 2] cycloaddition reaction of 2H-azirines with quinones has been developed under mild reaction conditions. The reaction provides a general and efficient strategy for the synthesis of the benzo[f]isoindole-4,9-diones scaffold

Iron-Catalyzed Enantioselective Radical Carboazidation and Diazidation of α,β-Unsaturated Carbonyl Compounds

Azidation of alkenes is an efficient protocol to synthesize organic azides which are important structural motifs in organic synthesis. Enantioselective radical azidation, as a useful strategy to install a C-N3 bond, remains challenging due to the inherently instability and unique structure of radicals. Here, we disclose an efficient enantioselective radical carboazidation and diazidation of α,β-unsaturated ketones and amides catalyzed by chiral N,N′-dioxide/Fe(OTf)2 complexes. An array of substituted alkenes was transformed to the corresponding α-azido carbonyl derivatives in good to excellent enantioselectivities, benefiting the preparation of chiral α-amino ketones, vicinal amino alcohols, and vicinal diamines. Control experiments and mechanistic studies proved the radical pathway in the reaction process. The DFT calculations showed that the azido transferred to the radical intermediate via an intramolecular five-membered transition state with the internal nitrogen of the Fe-N3 species.

Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP

An efficient and user-friendly palladium(II) precatalyst, POxAP (post-oxidative-addition precatalyst), was identified for use in Fukuyama cross-coupling reactions. Suitable for storage under air, the POxAP precatalyst allowed reaction between thioesters and organozinc reagents with turnover numbers of ～90000. A series of 23 ketones were obtained with yields ranging from 53 to 99%. As proof of efficacy, an alternative approach was developed for the synthesis of a key precursor of the natural product isoprekinamycin.