62484-59-7

Basic information

• Product Name: 5(4H)-Oxazolone, 4-[(4-oxo-4H-1-benzopyran-3-yl)methylene]-2-phenyl-
• CAS NO: 62484-59-7
• Molecular Formula: C19H11NO4
• Molecular Weight: 317.301
• Mol File: 62484-59-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5(4H)-Oxazolone, 4-[(4-oxo-4H-1-benzopyran-3-yl)methylene]-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(4H)-Oxazolone, 4-[(4-oxo-4H-1-benzopyran-3-yl)methylene]-2-phenyl-(62484-59-7)
• EPA Substance Registry System: 5(4H)-Oxazolone, 4-[(4-oxo-4H-1-benzopyran-3-yl)methylene]-2-phenyl-(62484-59-7)

Safety Data

• Hazardous Substances Data: 62484-59-7(Hazardous Substances Data)

Usage

Molecular structure

Contains a oxazolone ring and a benzopyran moiety

Molecular weight

375.36 g/mol

Potential applications

Medicinal chemistry and drug discovery

Additional research needed

to fully understand properties and potential uses

Upstream product

• 98-88-4 benzoyl chloride 
• 495-69-2 Hippuric Acid 
• 17422-74-1 3-Formylchromone 

Downstream Products

• 132326-68-2 2-[2-(2-Acetoxy-phenyl)-5-benzoylamino-6-oxo-6H-pyran-3-ylmethylene]-malonic acid diethyl ester 
• 132286-94-3 2-[1-[2-(2-Acetoxy-phenyl)-5-benzoylamino-6-oxo-6H-pyran-3-yl]-meth-(Z)-ylidene]-3-oxo-butyric acid ethyl ester 
• 132326-66-0 Acetic acid 2-[3-(2-acetyl-3-oxo-but-1-enyl)-5-benzoylamino-6-oxo-6H-pyran-2-yl]-phenyl ester 
• 95539-04-1 4,5-dihydro-1-p-methoxyphenyl-4-<4-oxo-4H-1-benzopyran-3-yl)methylene>-2-phenylimidazol-5-one 
• 95538-94-6 (E)-2-Benzoylamino-3-(4-oxo-4H-chromen-3-yl)-acrylic acid methyl ester 
• 95538-95-7 N,N-diethyl-4-(2-hydroxybenzoyl)pyrrole-2-carboxamide 
• 132326-64-8 2-(3-Benzoylamino-2-oxo-2H,5H-pyrano[3,2-c]chromen-5-yl)-3-oxo-butyric acid ethyl ester 
• 95538-90-2 N-[(E)-2-(4-Oxo-4H-chromen-3-yl)-1-(piperidine-1-carbonyl)-vinyl]-benzamide 
• 95539-00-7 N-[(E)-1-(4-Methoxy-phenylcarbamoyl)-2-(4-oxo-4H-chromen-3-yl)-vinyl]-benzamide 
• 95538-93-5 (E)-2-Benzoylamino-3-(4-oxo-4H-chromen-3-yl)-acrylic acid 
• 95538-97-9 3-benzoylamino-5-ethoxy-2-oxo-2H,5H-pyrano<3,2-c><1>benzopyrane 
• 62484-63-3 methyl 4-(2-hydroxybenzoyl)-1H-pyrrole-2-carboxylate 
• 132326-62-6 2-(3-Benzoylamino-2-oxo-2H,5H-pyrano[3,2-c]chromen-5-yl)-malonic acid diethyl ester 
• 132326-60-4 N-[5-(1-Acetyl-2-oxo-propyl)-2-oxo-2H,5H-pyrano[3,2-c]chromen-3-yl]-benzamide 

Relevant articles and documents

Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives

Four series of sulfonamides incorporating chromone moieties were synthesized and assessed for their cytotoxic activity against MCF-7 and A-549 cell lines, considering the fact that some of these tumors overexpress isoforms of carbonic anhydrase (CA, EC 4.2.1.1) which is inhibited by sulfonamides. Most new sulfonamides showed weak inhibitory activity against the offtarget, cytosolic isoforms hCA I, II but effectively inhibited the tumor-associated hCA IX and XII. The most active compounds featured a primary SO2NH2 group and were active in the low micromolar range against MCF-7 and A-549 cell lines. Compound 4a showed IC50 of 0.72 and 0.50 1/4M against MCF-7 and A-549 cell lines, respectively, and was further evaluated for its proapoptotic activity which proved enhanced in both tumor types.