625080-61-7

Basic information

• Product Name: 4-benzylamino-6,7-difluoroquinazoline
• Synonyms: 4-benzylamino-6,7-difluoroquinazoline
• CAS NO: 625080-61-7
• Molecular Weight: 271.269
• Mol File: 625080-61-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-benzylamino-6,7-difluoroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzylamino-6,7-difluoroquinazoline(625080-61-7)
• EPA Substance Registry System: 4-benzylamino-6,7-difluoroquinazoline(625080-61-7)

Safety Data

• Hazardous Substances Data: 625080-61-7(Hazardous Substances Data)

Upstream product

• 211374-80-0 2-amino-4,5-difluorobenzamide 
• 205259-37-6 6,7-difluoro-3,4-dihydroquinazolin-4-one 
• 100-46-9 benzylamine 
• 625080-60-6 4-chloro-6,7-difluoroquinazoline 

Relevant articles and documents

Structure-activity relationships of 6-fluoroquinazolines: Dual-Acting compounds with inhibitory activities toward both TNF-α production and T cell proliferation

We synthesized various 6-fluoro-7-(1-piperazino)quinazolines based on the structure of 1 and evaluated their inhibitory activities toward both TNF-α production and T cell proliferation responses. Among these compounds, 7a, having the 3,4-(methylenedioxy)phenyl moiety at the C(4)-position of the quinazoline ring, showed both inhibitory activities. Furthermore, the oral treatment with 7a exhibited an anti-inflammatory effect in rats with adjuvant arthritis as well as an inhibitory activity toward LPS-induced TNF-α production.