62567-42-4

Basic information

• Product Name: 6-(2-HYDROXYPHENYL)-PYRIDAZIN-3(2H)-ONE&
• Synonyms: 6-(2-Hydroxyphenyl)-3(2H)-pyridazinone
• CAS NO: 62567-42-4
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.18
• EINECS: 263-598-4
• Product Categories: Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Pyridazines
• Mol File: 62567-42-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 297-302 °C(lit.)
• Boiling Point: 333.1°Cat760mmHg
• Flash Point: 149.2°C
• Appearance: /
• Density: 1.336g/cm³
• Refractive Index: 1.651
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-(2-HYDROXYPHENYL)-PYRIDAZIN-3(2H)-ONE&(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2-HYDROXYPHENYL)-PYRIDAZIN-3(2H)-ONE&(62567-42-4)
• EPA Substance Registry System: 6-(2-HYDROXYPHENYL)-PYRIDAZIN-3(2H)-ONE&(62567-42-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 62567-42-4(Hazardous Substances Data)

Usage

General Description

6-(2-Hydroxyphenyl)-pyridazin-3(2H)-oneis a chemical compound that belongs to the pyridine family. It has a molecular formula of C11H8N2O2 and a molecular weight of 196.19 g/mol. 6-(2-HYDROXYPHENYL)-PYRIDAZIN-3(2H)-ONE& is a pyridazinone derivative and has potential biological and pharmaceutical applications. The presence of a hydroxyl group and a phenyl ring in its structure suggests it may have antioxidant and medicinal properties. Additionally, its pyridazinone core indicates potential use as a building block in the synthesis of various bioactive molecules. Overall, 6-(2-Hydroxyphenyl)-pyridazin-3(2H)-one is a versatile chemical that may have significance in various fields such as medicine, biology, and chemistry.

InChI:InChI=1/C10H8N2O2/c13-9-4-2-1-3-7(9)8-5-6-10(14)12-11-8/h1-6,13H,(H,12,14)

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 298-12-4 Glyoxilic acid 
• 7250-94-4 o-acetoxyacetophenone 
• 90125-51-2 2-hydroxy-4-oxo-4-(2-hydroxyphenyl)butyric acid 
• 127-68-4 sodium 3-nitrobenzenesulfonate 
• 39499-60-0 6-(2-hydroxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one 

Downstream Products

• 77585-94-5 3-chloro-6-(2-hydroxyphenyl)pyridazine 

Relevant articles and documents

Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease

Based on multitarget-directed ligands approach, through two rounds of screening, a series of 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives were designed, synthesized and evaluated as innovative multifunctional agents against Alzheimer's disease. In vitro biological assays indicated that most of the hybrids were endowed with great AChE inhibitory activity, excellent antioxidant activity and moderate Aβ1-42 aggregation inhibition. Taken both efficacy and balance into account, 12a was identified as the optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC50 = 0.20 μM; HuAChE, IC50 = 37.02 nM) and anti-Aβ activity (IC50 = 1.92 μM for self-induced Aβ1-42 aggregation; IC50 = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC50 = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC50 = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils; 81.7% for HuAChE-induced Aβ1-40 aggregation). Moreover, it was equipped with the potential to serve as antioxidant (3.03 Trolox equivalents), metals chelator and anti-neuroinflammation agent for synergetic treatment. Finally, in vivo study demonstrated that 12a, with suitable BBB permeability (log BB = ?0.61), could efficaciously ameliorate cognitive dysfunction on scopolamine-treated mice by regulating cholinergic system and oxidative stress simultaneously. Altogether, these results highlight the potential of 12a as an innovative balanced multifunctional candidate for Alzheimer's disease treatment.

Process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone

A process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone which comprises reacting 2-hydroxyacetophenone with glyoxylic acid under alkaline conditions, adjusting the pH of the reaction mixture to give a mixture within a pH range of about pH 4.0-9.5 and which contains a weak base, and subsequently reacting with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinone is a useful intermediate in the preparation of anti-hypertensive agents.

1,1,1-Trihalo-2-hydroxy-4-(2-hydroxyphenyl)-4-butanones

A new synthesis for the preparation of 6-(2-hydrophenyl)-3-pyridazinones whose key reaction is cyclizing a 1,1,1-trihalo-2-hydroxy-4-(2-hydroxyphenyl)-4-butanone with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinones are important intermediates for preparing medicinally active compounds especially 3-[2-(3-tert.-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine or its nontoxic acid addition salts. The invention claimed here is the trihalocarbinol intermediates.