62574-33-8Relevant articles and documents
Disulfide linked pyrazole derivatives inhibit phagocytosis of opsonized blood cells
Purohit, Meena K.,Scovell, Iain,Neschadim, Anton,Katsman, Yulia,Branch, Donald R.,Kotra, Lakshmi P.
, p. 2324 - 2327 (2013/05/09)
Immune thrombocytopenia (ITP) is caused by production of an autoantibody to autologous platelets. ITP can be treated either by reducing platelet destruction or by increasing platelet production. Fcγ receptor mediated phagocytosis of the opsonized blood ce
Synthesis of substituted 3-phenyl-6H-pyrazolo[4,3-d]isoxazoles from corresponding 4-benzoyl-5-hydroxypyrazoles
Holzer, Wolfgang,Hahn, Katharina
, p. 303 - 308 (2007/10/03)
Treatment of 1,(3)-(di)substituted 4-benzoyl-5-hydroxypyrazoles with phosphorus oxychloride affords the corresponding 4-benzoyl-5-chloropyrazoles. Reaction of the latter with hydroxylamine leads to oximes, which can be cyclized to novel 3-phenyl-6H-pyrazolo[4,3-d]isoxazoles by treatment with sodium hydride in dimethyl formamide. Detailed nmr spectroscopic studies (1H, 13C) with all obtained compounds are presented.