6259-79-6

Basic information

• Product Name: Hexyl Salicylate
• Synonyms: Benzoic acid, 4-[bis(2-chloroethyl)amino]-, ethyl ester
• CAS NO: 6259-79-6
• Molecular Formula: C₁₃H₁₇Cl₂NO₂
• Molecular Weight: 290.19
• Mol File: 6259-79-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 406.7°C at 760 mmHg
• Flash Point: 199.8°C
• Appearance: /
• Density: 1.221g/cm³
• Vapor Pressure: 7.99E-07mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: Hexyl Salicylate(CAS DataBase Reference)
• NIST Chemistry Reference: Hexyl Salicylate(6259-79-6)
• EPA Substance Registry System: Hexyl Salicylate(6259-79-6)

Safety Data

• Hazardous Substances Data: 6259-79-6(Hazardous Substances Data)

Usage

General Description

Hexyl salicylate is a chemical compound commonly used in the fragrance industry as a scent ingredient. It is a clear, colorless liquid with a floral, sweet, and somewhat fruity odor that is reminiscent of lily of the valley. It is also known for its ability to provide a long-lasting and rich fragrance, making it a popular choice in perfumes, lotions, soaps, and other scented products. In addition to its use in the beauty and personal care industry, hexyl salicylate also has emollient properties, making it valuable for moisturizing and conditioning the skin. However,

InChI:InChI=1/C13H17Cl2NO2/c1-2-18-13(17)11-3-5-12(6-4-11)16(9-7-14)10-8-15/h3-6H,2,7-10H2,1H3

Upstream product

• 15716-30-0 ethyl 4-benzoate 
• 94-09-7 p-aminoethylbenzoate 
• 150-13-0 4-amino-benzoic acid 
• 62-23-7 4-nitro-benzoic acid 

Downstream Products

• 1141-37-3 4-{bis(2-chloroethyl)amino}benzoic acid 
• 305-03-3 chlorambucil 

Relevant articles and documents

Design and synthesis of chromone-nitrogen mustard derivatives and evaluation of anti-breast cancer activity

Chromone has emerged as one of the most important synthetic scaffolds for antitumor activity, which promotes the development of candidate drugs with better activity. In this study, a series of nitrogen mustard derivatives of chromone were designed and syn

Improving the Potency of Cancer Immunotherapy by Dual Targeting of IDO1 and DNA

Herein we report the first exploration of a dual-targeting drug design strategy to improve the efficacy of small-molecule cancer immunotherapy. New hybrids of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors and DNA alkylating nitrogen mustards that respectively target IDO1 and DNA were rationally designed. As the first-in-class examples of such molecules, they were found to exhibit significantly enhanced anticancer activity in vitro and in vivo with low toxicity. This proof-of-concept study has established a critical step toward the development of a novel and effective immunotherapy for the treatment of cancers.

Design, synthesis and biological evaluation of novel sesquiterpene mustards as potential anticancer agents

Several novel series of sesquiterpene mustards (SMs) bearing nitrogen mustard and glutathione (GSH)-reactive α-methylene-γ-butyrolactone groups were successfully prepared for the first time and showed excellent antiproliferative activities in vitro. Among them, compounds 2e and 2g displayed the highest antiproliferative properties with IC50 values ranging from 2.5 to 8.7 μM. The selectivity of these two compounds was evaluated by SRB method against human cancer and normal hepatic cells (HepG2 and L02). The induction of apoptosis and effects on the cell cycle distribution with compounds 2e and 2g were investigated by Hoechst 33,258 staining and flow cytometry, which exhibited that they could induce selective cell apoptosis and cell cycle arrest in HepG2 and L02 cells. In addition, further investigation showed that compounds 2e and 2g could obviously inhibit the proliferation of HepG2 cells by inducing significant DNA cross-linking and depleting GSH in cell media. The good cytotoxicity and selectivity of compounds 2e and 2g pointed them as promising leads for anticancer drug design.