62596-28-5

Basic information

• Product Name: Cyclohexanone, 2-[(4-methylphenyl)methyl]-
• CAS NO: 62596-28-5
• Molecular Formula: C14H18O
• Molecular Weight: 202.296
• Mol File: 62596-28-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 2-[(4-methylphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 2-[(4-methylphenyl)methyl]-(62596-28-5)
• EPA Substance Registry System: Cyclohexanone, 2-[(4-methylphenyl)methyl]-(62596-28-5)

Safety Data

• Hazardous Substances Data: 62596-28-5(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 104-82-5 4-Methylbenzyl chloride 
• 39209-07-9 2-methylcyclohexanone O-methyl oxime 
• 123726-16-9 bis(4-methylphenyl)iodonium trifluoromethanesulfonate 
• 104-81-4 4-Methylbenzyl bromide 
• 589-18-4 4-Methylbenzyl alcohol 

Downstream Products

• 144147-75-1 2-(2,2-Dimethoxy-acetyl)-6-(4-methyl-benzyl)-cyclohexanone 
• 144149-42-8 (E)-3-[2-(4-Fluoro-phenyl)-7-(4-methyl-benzyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl]-propenal 
• 144148-20-9 2-(4-Fluoro-phenyl)-7-(4-methyl-benzyl)-4,5,6,7-tetrahydro-2H-indazole-3-carbaldehyde 

Relevant articles and documents

Synthesis and structural characterization of facile ruthenium(II) hydrazone complexes: Efficient catalysts in α-alkylation of ketones with primary alcohols via hydrogen auto transfer

As a immersion for development of new complexes, new Ru(II) complexes (1–3) supported by benzothiazole hydrazine Schiff bases of the type [Ru(SAL-HBT)(CO)(AsPh3)2], [Ru(VAN-HBT)(CO)(AsPh3)2] and [Ru(NAP-HBT)(CO)Cl(AsPh3)2] [SAL-HBT = (salicyl((2-(benzothiazol-2yl)hydrazono)methylphenol)), VAN-HBT = 2-((2-(benzothiazol-2-yl)hydrazono)methyl)-6 methoxyphenol) and NAP-HBT = naphtyl-2-((2-(benzothiazol-2-yl)hydrazono)methyl phenol)] were synthesized. Their identities have been established by satisfactory elemental analyses, various spectroscopic techniques (IR, (1H, 13C) NMR) and also mass spectrometry. The ruthenium(II) ion exhibits a hexa coordination with distorted octahedral geometry. In complexes 1 and 2, the ligand coordinated as dianionic tridentate fashion by forming N^N donor five member and N^O donor six member chelate rings. However, in complex 3, the ligand coordinated as monoanionic bidentate fashion by forming N^N donor five-membered ring. The new ruthenium(II) carbonyl complexes were successfully applied as catalysts in α -alkylation of aliphatic and aromatic ketones with alcohols via borrowing hydrogen strategy. Various parameters such as base, solvent, temperature, time and catalyst loading on the catalytic activity were analyzed. From the results, the catalyst 1 was found to be the best catalyst for α-alkylation reaction to obtain excellent yield. The catalytic system has a broad substrate scope, which allows the synthesis of α-alkylated ketones in mild reaction conditions with low catalyst loading under air atmosphere.

β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp 3)-H bonds using a palladium catalyst

An efficient method of selective β-arylation of oxime ethers was realized by using a palladium catalyst with diaryliodonium salts as the key arylation reagents. The reaction proceeded smoothly through the activation of inert C(sp3)-H bonds to give corresponding ketones and aldehydes. This convenient procedure can be successfully applied to construct new C(sp3)-C(sp2) bonds on a number of complex molecules derived from natural products and thus serves as a practical synthetic tool for direct late-stage C(sp3)-H functionalization.