62617-91-8Relevant articles and documents
IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
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Page/Page column 194; 195, (2014/02/15)
A series of imidazo[l,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Catalytic Reaction. 1. Catalytic 1,4-Hydrogenation of α,β-Unsaturated Aldehydes and Ketones using SC-1 Nickel Boride
Belisle, Christopher M.,Young, Yvette M.,Singaram, Bakthan
, p. 5594 - 5598 (2007/10/02)
Ex-situ generated Sc-1 nickelboride (SC-1 Ni2B), prepared by refluxing nickel chloride and sodium borohydride in methanol, is used in the selective 1,4-hydrogenation of α,β-unsaturated ketones and aldehydes at one atmospheric pressure.Previous studies of in-situ generated Ni2B have had the disadvantage of the undesirable side reaction of sodium borohydride with the various functional groups.In contrast, our catalyst cleanly gives the corresponding saturated aldehyde or ketone with no detectable amounts of saturated alcohol.Furthermore, the degree of substitution of the double bond plays a significant role in the rate of hydrogenation.While unsaturated carbonyl compounds containing di- and tri- substituted duoble bonds are readily hydrogenated, tetrasubstituted double bond containing carbonyl compounds are highly unreactive.
Carbonyl Compounds by Osmium Tetroxide Oxidation: Preferential Oxidation of Primary over Secondary Hydroxy Groups
Maione, Anna Maria,Romeo, Aurelio
, p. 955 - 957 (2007/10/02)
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