62635-27-2Relevant articles and documents
Reduction of activated carbonyl groups using alkylphosphanes as reducing agents: A mechanistic study
Wei, Yin,Liu, Xu-Guang,Shi, Min
scheme or table, p. 2386 - 2393 (2012/06/04)
A comprehensive mechanistic investigation on the reduction of activated carbonyl groups using alkylphosphanes as reducing agents has been conducted through a combination of experimental as well as computational studies. Both approaches show that this kind of reduction proceeds either through proton transfer from alkylphosphanes and cleavage by water during work-up or through another reaction pathway involving the participation of water at the initial stage and a two-fold proton transfer to afford the product. The reaction mechanism of the reduction of activated carbonyl groups using alkylphosphanes has been studied both experimentally and theoretically. The reduction was shown to proceed either through proton transfer from alkylphosphanes and cleavage by water during work-up or through the participation of water at the initial stage and a two-fold proton transfer.