62648-61-7

Basic information

• Product Name: diethyl (morpholin-4-ylmethylidene)propanedioate
• CAS NO: 62648-61-7
• Molecular Formula: C₁₂H₁₉NO₅
• Molecular Weight: 257.283
• Mol File: 62648-61-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 322.4°C at 760 mmHg
• Flash Point: 148.8°C
• Density: 1.203g/cm³
• Vapor Pressure: 0.00028mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: diethyl (morpholin-4-ylmethylidene)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (morpholin-4-ylmethylidene)propanedioate(62648-61-7)
• EPA Substance Registry System: diethyl (morpholin-4-ylmethylidene)propanedioate(62648-61-7)

Safety Data

• Hazardous Substances Data: 62648-61-7(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 22630-09-7 trimorpholylmethane 
• 105-53-3 diethyl malonate 

Downstream Products

• 101419-83-4 4-[(E)-2-nitrovinyl]morpholine 
• 98771-59-6 ethyl 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate 

Relevant articles and documents

Reaction of Ortho Esters with Secondary Amines

The scope of the reaction of ortho esters with secondary amines has been explored.With p-toluenesulfonic acid as catalyst, N-alkylanilines and orthoformates gave high yields of N-alkylformanilides and N,N-dialkylanilines in contrast to previous work with other acid catalysts where ortho amides were produced in low yield.Aliphatic cyclic amines (e.g., morpholine, piperidine) and orthoformates gave the corresponding ortho amides.This constitutes a new convenient synthesis of these useful reagents.