6266-22-4Relevant articles and documents
Valorization of chitin derived N-acetyl-D-glucosamine into high valuable N-containing 3-acetamido-5-acetylfuran using pyridinium-based ionic liquids
Zang, Hongjun,Lou, Jing,Jiao, Shuolei,Li, Huanxin,Du, Yannan,Wang, Jiao
, (2021/02/26)
Chitin and its derivatives contain biologically fixed nitrogen elements, which can provide nitrogen sources for N-containing chemicals. Herein, a series of pyridinium-based ionic liquids were synthesized to directly catalyze the conversion of N-acetyl-D-glucosamine (NAG, the monomer of chitin) to 3-acetamido-5-acetylfuran (3A5AF). The yield of 3A5AF in 1-carboxymethyl pyridinium chloride ionic liquid reached 37.49%, without any additives. Using B2O3 and CaCl2 as additives, the optimum yield increased to 67.37% at 180 °C in 20 min. In addition, HPLC-MS analysis has been utilized to elucidate the reaction mechanism. This research on turning “waste” into “wealth” opens up new ways for the utilization of biomass waste, which not only reduces environmental pollution but also has potential economic value.
Benzimidazolone as potent chymase inhibitor: Modulation of reactive metabolite formation in the hydrophobic (P1) region
Lo, Ho Yin,Nemoto, Peter A.,Kim, Jin Mi,Hao, Ming-Hong,Qian, Kevin C.,Farrow, Neil A.,Albaugh, Daniel R.,Fowler, Danielle M.,Schneiderman, Richard D.,Michael August,Martin, Leslie,Hill-Drzewi, Melissa,Pullen, Steven S.,Takahashi, Hidenori,De Lombaert, Stephane
scheme or table, p. 4533 - 4539 (2011/09/12)
A new class of chymase inhibitor featuring a benzimidazolone core with an acid side chain and a P1 hydrophobic moiety is described. Incubation of the lead compound with GSH resulted in the formation of a GSH conjugate on the benzothiophene P1 moiety. Replacement of the benzothiophene with different heterocyclic systems such as indoles and benzoisothiazole is feasible. Among the P1 replacements, benzoisothiazole prevents the formation of GSH conjugate and an in silico analysis of oxidative potentials agreed with the experimental outcome.
BENZIMIDAZOLONE CHYMASE INHIBITORS
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Page/Page column 231-232, (2009/01/20)
Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.