6266-57-5

Basic information

• Product Name: 1,2-bis(3-methoxyphenyl)ethanone
• CAS NO: 6266-57-5
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.2964
• Mol File: 6266-57-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 393.7°C at 760 mmHg
• Flash Point: 183.4°C
• Density: 1.115g/cm³
• Vapor Pressure: 2.09E-06mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 1,2-bis(3-methoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis(3-methoxyphenyl)ethanone(6266-57-5)
• EPA Substance Registry System: 1,2-bis(3-methoxyphenyl)ethanone(6266-57-5)

Safety Data

• Hazardous Substances Data: 6266-57-5(Hazardous Substances Data)

Usage

Class

Aromatic ketones

Physical State

Crystalline solid

Odor

Slightly aromatic

Usage

Flavoring agent in the food industry

Profile

Sweet and aromatic

Additional Use

Production of perfumes and fragrances

Investigation

Potential pharmaceutical applications

Specific Applications

Development of novel anti-inflammatory and analgesic drugs

Safety Precaution

Can cause skin and eye irritation

Handling

Exercise caution when handling the compound

Upstream product

• 6706-95-2 3,3'-dimethoxybenzoin 
• 5813-86-5 m-methoxybenzamide 
• 26905-40-8 3-methoxybenzylmagnesium chloride 
• 1711-05-3 m-anisoyl chloride 
• 6325-63-9 1,2-bis(3-methoxyphenyl)ethylene 
• 507-36-8 2-bromo-2-methylbutane 
• 1527-89-5 3-methoxybenzonitrile 

Downstream Products

• 5471-44-3 3,3'-dimethoxy-deoxybenzoin oxime 
• 345927-21-1 1,2-bis-(3-methoxy-phenyl)-butan-1-one 
• 97059-61-5 5,6-bis-(3-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 
• 97059-77-3 5,6-Bis-(3-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 1-oxide 
• 82333-59-3 C₂₄H₂₄O₂ 
• 82333-64-0 C₂₅H₂₆O₃ 
• 82333-61-7 C₂₅H₂₆O₃ 
• 82333-77-5 Acetic acid 3-[1,2-bis-(3-acetoxy-phenyl)-but-1-enyl]-phenyl ester 
• 82333-74-2 Acetic acid 3-[(Z)-2-(3-acetoxy-phenyl)-1-phenyl-but-1-enyl]-phenyl ester 
• 82333-75-3 Acetic acid 3-[(E)-2-(3-acetoxy-phenyl)-1-phenyl-but-1-enyl]-phenyl ester 
• 82333-79-7 Acetic acid 3-[(Z)-2-(3-acetoxy-phenyl)-1-(4-acetoxy-phenyl)-but-1-enyl]-phenyl ester 
• 82333-80-0 Acetic acid 3-[(E)-2-(3-acetoxy-phenyl)-1-(4-acetoxy-phenyl)-but-1-enyl]-phenyl ester 
• 5959-71-7 MetaDES 

Relevant articles and documents

Ni/Ti Dual Catalytic Cross-Coupling of Nitriles and Organobromides to Access Ketones

Herein, we report the development of a dual catalytic approach for the cross-coupling of nitriles with aryl- and aliphatic-bromides. A titanium(III) catalyst is used to activate nitriles enabling their coupling with organobromides through a nickel catalyst. The Ni/Ti system efficiently prepared unsymmetrical ketones with good chemoselectivity and could selectively couple a bromide in the presence of other functionalizable handles.

REDUCTIVE COUPLING OF BENZOIC ACID HALIDES AND ESTERS USING LOW-VALENT TITANIUM

The reductive coupling of (substituted) benzoic acid chlorides and esters is achieved using low-valent titanium, generated from TiCl3 and LiAlH4.Both acid chlorides and esters seem to follow the same two reaction pathways: one path via tolanes to stilbenes, the other via benzils to complex mixtures of products arising from reduction and further coupling reactions.Although the exact product balance depends upon the reaction conditions the major product is (substituted) cis-stilbene.