626604-39-5 Usage
General Description
GSK-3β Inhibitor XI is a potent and selective inhibitor of glycogen synthase kinase-3 beta (GSK-3β), a key enzyme involved in various signaling pathways. This small molecule compound has been extensively studied for its potential therapeutic applications in a wide range of diseases, including cancer, neurological disorders, and inflammatory conditions. By blocking GSK-3β activity, GSK-3β Inhibitor XI can modulate multiple cellular processes, such as cell proliferation, apoptosis, and inflammation, making it a promising target for drug development. Its high selectivity and potency make it a valuable tool for researchers studying GSK-3β signaling and exploring potential therapeutic interventions.
Check Digit Verification of cas no
The CAS Registry Mumber 626604-39-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,6,6,0 and 4 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 626604-39:
(8*6)+(7*2)+(6*6)+(5*6)+(4*0)+(3*4)+(2*3)+(1*9)=155
155 % 10 = 5
So 626604-39-5 is a valid CAS Registry Number.
626604-39-5Relevant articles and documents
Design, synthesis, and biological evaluation of novel 7-azaindolyl- heteroaryl-maleimides as potent and selective glycogen synthase kinase-3β (GSK-3β) inhibitors
O'Neill, David J.,Shen, Lan,Prouty, Catherine,Conway, Bruce R.,Westover, Lori,Xu, Jun Z.,Zhang, Han-Cheng,Maryanoff, Bruce E.,Murray, William V.,Demarest, Keith T.,Kuo, Gee-Hong
, p. 3167 - 3185 (2007/10/03)
Two approaches were developed to synthesize the novel 7-azaindolyl- heteroarylmaleimides. The first approach was based upon the palladium-catalyzed Suzuki cross-coupling or Stille cross-coupling of 2-chloro-maleimide 5 with various arylboronic acids or ar