62673-69-2

Basic information

• Product Name: GSK-3β Inhibitor VI
• Synonyms: GSK-3β Inhibitor VI
• CAS NO: 62673-69-2
• Molecular Formula: C₆H₃Br₂ClOS
• Molecular Weight: 318.41342
• EINECS: -0
• Product Categories: Other enzyme inhibitors and activators;Other Enzyme Inhibitors and Activators.
• Mol File: 62673-69-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: GSK-3β Inhibitor VI(CAS DataBase Reference)
• NIST Chemistry Reference: GSK-3β Inhibitor VI(62673-69-2)
• EPA Substance Registry System: GSK-3β Inhibitor VI(62673-69-2)

Safety Data

• Hazardous Substances Data: 62673-69-2(Hazardous Substances Data)

Usage

Uses

A thienyl -chloromethyl ketone compound that acts as a cell-permeable, irreversible, and non-ATP competitive inhibitor of GSK-3

Upstream product

• 3140-93-0 2,3-dibromothiophen 
• 79-04-9 chloroacetyl chloride 
• 3141-24-0 2,3,5-tribromothiophene 

Relevant articles and documents

Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools

Thienylhalomethylketones, whose chemical, biological, and pharmaceutical data are here reported, are the first irreversible inhibitors of GSK-3β described to date. Their inhibitory activity is likely related to the cysteine residue present in the ATP-binding site, which is proposed as a relevant residue for modulation of GSK-3 activity. The good cell permeability of the compounds allows them to be used in different cell models. Overall, the results presented here support the potential use of halomethylketones as pharmacological tools for the study of GSK-3β functions and suggest a new mechanism for GSK-3β inhibition that may be considered for further drug design.

Bromothiophene Reactions. I. Friedel-Crafts Acylation

Friedel-Crafts acylation of 2,5-dibromo- and 2,3,5-tribromothiophenes with different acyl chlorides and anhydrous aluminium trichloride has been studied.The reaction afforded a mixture of acyl derivatives and tetrabromothiophene.The results obtained suggest a mechanism which involves the formation of bromine cations in the reaction medium.Several products obtained in this reaction are described.