627-95-2 Usage
Description
5-Aminovaleric Acid Hydrochloride is an organic compound with the chemical formula C5H12ClNO2. It is a light pink crystalline powder that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. Its chemical structure allows it to participate in multiple reactions, making it a versatile building block in the development of new drugs and therapeutic agents.
Uses
Used in Pharmaceutical Industry:
5-Aminovaleric Acid Hydrochloride is used as a synthetic precursor for the production of antibiotics, specifically antibiotics XIV. It plays a vital role in the development of new antibiotics to combat bacterial infections and contribute to the ongoing fight against antibiotic resistance.
Used in Research and Development:
5-AMINOVALERIC ACID HYDROCHLORIDE is also utilized as a reagent in the study of the reaction between thiolactams and ethyl chloroacetate. Understanding these reactions can lead to the discovery of new chemical pathways and the development of novel pharmaceutical compounds.
Used in the Synthesis of Hydroxymethyl Dihydroisoxazole Derivatives:
5-Aminovaleric Acid Hydrochloride is employed as a key component in the synthesis of hydroxymethyl dihydroisoxazole derivatives. These derivatives have potential applications as antibiotic agents, further expanding the utility of this compound in the pharmaceutical sector.
Purification Methods
Crystallise the salt from CHCl3. Otherwise dissolve it in EtOH and add 2 volumes of Et2O and chill. [Schniepp & Marvel J Am Chem Soc 57 1557 1935, Woods & Colver J Am Chem Soc 67 654 1945, Beilstein 4 III 1343, 4 IV 2636.]
Check Digit Verification of cas no
The CAS Registry Mumber 627-95-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 7 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 627-95:
(5*6)+(4*2)+(3*7)+(2*9)+(1*5)=82
82 % 10 = 2
So 627-95-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H11NO2.ClH/c6-4-2-1-3-5(7)8;/h1-4,6H2,(H,7,8);1H
627-95-2Relevant articles and documents
An Efficient Two-Step Preparation of α-, β-, γ- or δ-Amino Acids from 2-Pyrazinones, 2-Hydroxypyrimidines or 2-Pyridones Respectively
Zacharie, Boulos,Abbott, Shaun D.,Baigent, Christopher B.,Doyle, Christopher,Yalagala, Ravi Shekar
, p. 6486 - 6493 (2018/11/23)
A practical and efficient two-step procedure is reported for the preparation of a variety of α-, β-, γ- and δ-amino acids from 2-pyridone, 2-pyrazinone or 2-hydroxypyrimidine and derivatives. The procedure is amenable to scale-up and in most cases no chromatographic purification of the product is required. This approach is useful, especially in the synthesis of amino acids or deuterated amino acids that are not obtained by other methods.
Transkarbams as transdermal permeation enhancers: Effects of ester position and ammonium carbamate formation
Novotny, Michal,Hrabálek, Alexandr,Jan??ová, Barbora,Novotny, Jakub,Vávrová, Kate?ina
scheme or table, p. 2726 - 2728 (2010/08/04)
Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group.
Synthesis of 2-Amino Acids via Selective Mono-N-alkylation of Trichloroacetamide by 2-Bromo Carboxylic Esters under Solid-Liquid Phase-Transfer Catalysis Conditions
Albanese, Domenico,Landini, Dario,Penso, Michele
, p. 1603 - 1605 (2007/10/02)
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