6274-53-9

Basic information

• Product Name: N-{2-[(phenylsulfonyl)amino]ethyl}acetamide
• Synonyms: acetamide, N-[2-[(phenylsulfonyl)amino]ethyl]-
• CAS NO: 6274-53-9
• Molecular Formula: C₁₀H₁₄N₂O₃S
• Molecular Weight: 242.2948
• Mol File: 6274-53-9.mol
• Article Data: 1

Chemical Properties

• Density: 1.239g/cm³
• Refractive Index: 1.541
• CAS DataBase Reference: N-{2-[(phenylsulfonyl)amino]ethyl}acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-[(phenylsulfonyl)amino]ethyl}acetamide(6274-53-9)
• EPA Substance Registry System: N-{2-[(phenylsulfonyl)amino]ethyl}acetamide(6274-53-9)

Safety Data

• Hazardous Substances Data: 6274-53-9(Hazardous Substances Data)

Upstream product

• 1001-53-2 monoacetylaminoethylamine 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 42988-32-9 N-(2-aminoethyl)benzenesulfonamide 
• 110-72-5 N-ethylethane-1,2-diamine 
• 4152-09-4 N-benzylethylenediamine 
• 109-81-9 N-methyl-ethane-1,2-diamine 

Relevant articles and documents

Direct β- and γ-C(sp3)?H Alkynylation of Free Carboxylic Acids**

In this study we report the identification of a novel class of ligands for palladium-catalyzed C(sp3)?H activation that enables the direct alkynylation of free carboxylic acid substrates. In contrast to previous synthetic methods, no introduction/removal of an exogenous directing group is required. A broad scope of acids including both α-quaternary and challenging α-non-quaternary can be used as substrates. Additionally, the alkynylation in the distal γ-position is reported. Finally, this study encompasses preliminary findings on an enantioselective variant of the title transformation as well as synthetic applications of the products obtained.