62772-73-0

Basic information

• Product Name: Imidazo[2,1-b]thiazole-5-carboxamide, 6-methyl-N-phenyl-
• CAS NO: 62772-73-0
• Molecular Formula: C13H11N3OS
• Molecular Weight: 257.316
• Mol File: 62772-73-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Imidazo[2,1-b]thiazole-5-carboxamide, 6-methyl-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[2,1-b]thiazole-5-carboxamide, 6-methyl-N-phenyl-(62772-73-0)
• EPA Substance Registry System: Imidazo[2,1-b]thiazole-5-carboxamide, 6-methyl-N-phenyl-(62772-73-0)

Safety Data

• Hazardous Substances Data: 62772-73-0(Hazardous Substances Data)

Upstream product

• 96-50-4 2-thiazolylamine 
• 31844-92-5 2-chloro-N-phenyl-3-oxobutanamide 
• 77628-51-4 6-methylimidazo<2,1-b>thiazole-5-carboxylic acid 
• 62-53-3 aniline 
• 57626-37-6 ethyl 6-methylimidazo<2.1-b>thiazole-5-carboxylate 

Relevant articles and documents

Design, synthesis and biological evaluation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors

In the present study, we have designed imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives from earlier reported imidazo[1,2-a]pyridine based Mycobacterium tuberculosis (MTB) pantothenate synthetase (PS) inhibitors. We synthesized thirty compounds and they were evaluated for MTB PS inhibition study, in vitro anti-TB activities against replicative and non-replicative MTB, in vivo activity using Mycobacterium marinum infected Zebra fish and cytotoxicity against RAW 264.7 cell line. Among them compound 2-methyl-N′-(4-phenoxybenzoyl)benzo[d]imidazo[2,1-b]thiazole-3-carbohydrazide (5bc) emerged as potent compound active against MTB PS with IC50 of 0.53 ± 0.13 μM, MIC of 3.53 μM, 2.1 log reduction against nutrient starved MTB, with 33% cytotoxicity at 50 μM. It also showed 1.5 log reduction of M. marinum load in Zebra fish at 10 mg/kg.