62778-11-4

Basic information

• Product Name: Pyridine hydrofluoride
• Synonyms: PYRIDINIUM POLY(HYDROGEN FLUORIDE);PYRIDINIUM POLY(HYDROGEN FLUORIDE) COMPLEX;PYRIDINE POLYFLUORIDE HYDROFLUORIDE;HF-PYRIDINE;HF;HF 55% IN PYRIDINE;HF 70% IN PYRIDINE;HYDROGEN FLUORIDE PYRIDINE COMPLEX
• CAS NO: 62778-11-4
• Molecular Formula: C5H6FN
• Molecular Weight: 99.11
• EINECS: 250-889-6
• Product Categories: Fluorinating Reagents;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Fluorination;Halogenation;Nucleophilic Fluorinating Reagents;Pyridinium Compounds;Synthetic Organic Chemistry
• Mol File: 62778-11-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 50/1mm
• Flash Point: 20 °C
• Appearance: /
• Density: 1.1 g/mL at 20 °C(lit.)
• Vapor Pressure: 22.8mmHg at 25°C
• Storage Temp.: Keep Cold/Store in Nalgene
• Sensitive: Moisture Sensitive
• Merck: 6821
• BRN: 4750151
• CAS DataBase Reference: Pyridine hydrofluoride(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine hydrofluoride(62778-11-4)
• EPA Substance Registry System: Pyridine hydrofluoride(62778-11-4)

Safety Data

• Hazard Codes: T+,T,C,F
• Statements: 26/27/28-35-11
• Safety Statements: 26-28-36/37/39-45-16
• RIDADR: UN 1790 8/PG 1
• WGK Germany: 2
• F: 3-10
• HazardClass: 8
• Hazardous Substances Data: 62778-11-4(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

Fluorinating reagent; deprotecting reagent in peptide chemistry.

General Description

May contain or form low levels of calcium fluoride during storage. Presence of this does not impact the specification values.

InChI:InChI=1/C5H5N.HI/c1-2-4-6-5-3-1;/h1-5H;1H

Upstream product

• 110-86-1 pyridine 
• 7664-39-3 hydrogen fluoride 

Relevant articles and documents

METHOD FOR PRODUCING 1,2,2,2-TETRAFLUOROETHYL DICHLOROMETHYL ETHER

PROBLEM TO BE SOLVED: To provide a method for efficiently manufacturing a 1,2,2,2-tetrafluoroethyl dichloromethyl ether. SOLUTION: By chlorinating 1,2,2,2-tetrafluoroethyl methylether in the presence of a radical initiator or under light irradiation, a mixture of 1,2,2,2-tetrafluoroethyl dichloromethyl ether and 1,2,2,2-tetrafluoroethyl trichloromethylether of higher order chlorinated substance is obtained. Then the obtained mixture is subjected to hydrogenolysis reaction using hydrogen to efficiently convert 1,2,2,2-tetrafluoroethyl trichloromethylether, which is a by-product difficult to separate from the mixture, into 1,2,2,2-tetrafluoroethyl dichloromethyl ether. Also, a 1,2,2,2-tetrafluoroethyl difluoromethyl ether (desflurane) useful as an inhalation anesthetic can be produced using the 1,2,2,2-tetrafluoroethyl dichloromethyl ether. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPO&INPIT

IF5-pyridine-HF: Air- and moisture-stable fluorination reagent

IF5-pyridine-HF, an air- and moisture-stable solid, can be used as a fluorination reagent for the introduction of fluorine atoms to the α-position of the sulfur atom in sulfides. The desulfurizing-fluorination reactions of benzylic sulfides, thioacetals, and 2-(methylthio)-1,3-dithiane derivatives were also performed using this reagent.