62780-84-1Relevant articles and documents
Synthesis method of domperidone drug intermediate 1-(3-chloropropyl)-benzimidazolyl-2-one
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Paragraph 0007; 0018; 0019, (2016/11/21)
The invention relates to a synthesis method of a domperidone drug intermediate 1-(3-chloropropyl)-benzimidazolyl-2-one, which comprises the following steps: adding 0.19mol of 1-allylbenzoimidazolyl-2-one, 120-140ml of ethylene glycol and 0.26-0.28mol of sodium sulfite, heating to 35-40 DEG C, controlling the stirring rate at 110-130 rpm, dropwisely adding 0.23-0.25mol of 1-amido-3-bromo-propane within 2-3 hours, reacting for 4-5 hours, pouring the reaction product into a sodium chloride solution, extracting with cyclohexanol 5-7 times, drying the cyclohexanol extracting solution with calcium oxide, evaporating to remove the solvent to obtain oily 1-allyl-3-(3-chloropropyl)benzimidazolyl-2-one (3); and adding 120ml of phosphoric acid solution and 60ml of propionitrile into the oily product (3), controlling the stirring rate at 110-130 rpm, heating the solution to 70-75 DEG C, reacting for 3-4 hours, evaporating to remove partial propionitrile, cooling to precipitate a solid, filtering, washing the solid with salt solution, and dehydrating to obtain the 1-(3-chloropropyl)-benzimidazolyl-2-one.
1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
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, (2008/06/13)
Compounds of the class of 1-(benzazolyalkyl)piperidine derivatives useful as antiemetic agents.