627862-69-5Relevant articles and documents
Highly enantioselective catalytic cross-dehydrogenative coupling of n -carbamoyl tetrahydroisoquinolines and terminal alkynes
Sun, Shutao,Li, Chengkun,Floreancig, Paul E.,Lou, Hongxiang,Liu, Lei
supporting information, p. 1684 - 1687 (2015/04/14)
The first catalytic asymmetric cross-dehydrogenative coupling of cyclic carbamates and terminal alkynes has been established. The reaction features high enantiocontrol and excellent functional group tolerance and displays a wide range of structurally and electronically diverse carbamates as well as terminal alkynes. N-Acyl hemiaminals were identified as the reactive intermediates through preliminary control experiments. Employing readily removable carbamates as substrates rather than traditionally adopted N-aryl amines allows applications in complex molecule synthesis and therefore advances the C-H functionalization strategy to a synthetically useful level.
Catalyst-controlled stereoselective combinatorial synthesis
Tietze, Lutz F.,Rackelmann, Nils,Sekar, Govindasamy
, p. 4254 - 4257 (2007/10/03)
Stereochemical diversity as a novel concept in combinatorial chemistry for the synthesis of nonpeptidic biologically active compounds is introduced. As an example, the combination of the hydrogenation of imines in the presence of either enantiomer of a ch
