628-94-4 Usage
Description
Adipamide, also known as hexanedioic diamide, is a white powder or chunky substance that is slightly soluble in water. It is incompatible with strong oxidizing agents and can produce hazardous products and toxic fumes, such as carbon monoxide, carbon dioxide, and nitrogen oxides, upon combustion or decomposition. Exposure to adipamide through inhalation, ingestion, or skin absorption can cause adverse health effects, including irritation of the eyes, skin, mucous membranes, and the upper respiratory tract. However, there is no complete information available about the toxicological properties of this chemical.
Uses
1. Used in Chemical Synthesis:
Adipamide is used as a chemical intermediate in the preparation of bisimidates. Bisimidates are versatile compounds that find applications in various industries, including pharmaceuticals, materials science, and polymer chemistry.
2. Used in Pharmaceutical Industry:
In the pharmaceutical industry, adipamide can be utilized as a building block for the synthesis of various drug molecules. Its reactivity and compatibility with other chemical groups make it a valuable component in the development of new pharmaceutical compounds.
3. Used in Materials Science:
Adipamide's properties, such as its solubility and reactivity, make it a potential candidate for use in the development of new materials with specific properties. It can be used in the synthesis of polymers, coatings, and other materials with tailored characteristics for various applications.
4. Used in Polymer Chemistry:
Adipamide can be employed in the synthesis of polymers with specific properties, such as biodegradability, thermal stability, or mechanical strength. Its use in polymer chemistry can lead to the development of new materials for various industries, including packaging, automotive, and electronics.
Air & Water Reactions
Slightly soluble in water .
Reactivity Profile
ADIPAMIDE forms flammable gases with strong reducing agents. A very weak base. Mixing with dehydrating agents such as P2O5 or SOCl2 generates adiponitrile. Combustion generates toxic mixed oxides of nitrogen (NOx).
Health Hazard
Exposures to adipamide by inhalation, ingestion, or skin absorption cause adverse health
effects. The symptoms include irritation of the eyes, skin, mucous membranes, and upper
respiratory tract. There is no complete information about the toxicological properties of
the chemical.
Health Hazard
Exposures to adipamide cause health disorders such as irritation to the skin, eyes, and
respiratory system. No specifi c adverse health effects have been reported from human
exposure to polyhexamethylene adipamide, except for mechanical irritation of the skin
and eyes caused by particles. Signifi cant skin permeation and systemic toxicity after contact
appears unlikely. The compound is not likely to be hazardous by skin contact, but
cleansing the skin after use is advisable. If molten polymer gets on the skin, cool rapidly with cold water. Workers should not attempt to peel polymer from skin, but consult a
medical unit for treatment of thermal burn.
Fire Hazard
The flash point of ADIPAMIDE has not been determined, but ADIPAMIDE is probably combustible.
Safety Profile
Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NOx,.
storage
Adipamide should be kept stored in a cool, dry place, with containers tightly closed to
prevent moisture absorption and contamination.
storage
Workers should avoid repeated exposures to adipamide. During use, workers should wear
suitable protective clothing, self-contained breathing apparatus, chemical safety goggles,
rubber boots, and heavy rubber gloves.
Precautions
During use and handling of adipamide, workers should wear self-contained breathing
apparatus, rubber boots, heavy rubber gloves, and chemical safety goggles to avoid
splashing of material. A full-face mask respirator provides protection from eye irritation.
Workers should avoid exposure to high concentrations of dust. No specifi c intervention is
indicated as the compound is not likely to be hazardous by inhalation. Consult a physician
if necessary. If exposed to fumes from overheating or combustion, move to fresh air.
Consult a physician if symptoms persist.
Check Digit Verification of cas no
The CAS Registry Mumber 628-94-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 628-94:
(5*6)+(4*2)+(3*8)+(2*9)+(1*4)=84
84 % 10 = 4
So 628-94-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H11NO3/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H2,7,8)(H,9,10)
628-94-4Relevant articles and documents
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Erlenmeyer,Bischoff
, p. 412 (1944)
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Synthetic method of adiponitrile
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Page/Page column 0030-0032; 0035-0037; 0039-0041; 0043-0045; 0049, (2020/05/30)
The invention provides a synthetic method of adiponitrile. The target product adiponitrile can be obtained by taking 1, 3-butadiene which is relatively easy to obtain as an initial raw material, carrying out a hydroaminocarbonylation reaction on terminal olefin of 1, 3-butadiene and then dehydrating, and the whole preparation process is mild in condition, good in reaction selectivity, high in yield, clean and non-toxic in reaction raw material and catalyst and small in environmental pollution.
METHOD FOR PRODUCING ADIPAMIDE AS INTERMEDIATE FOR PRODUCTION OF RAW MATERIAL FOR BIO-BASED NYLON
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Paragraph 0064-0084, (2020/03/17)
Disclosed is a method for producing adipamide, which may include the steps of: (a) reacting glucose, nitric acid (HNO3), sodium nitrite (NaNO2) and potassium hydroxide (KOH) to produce a glucaric acidpotassium salt, (b) producing glucamide by reacting the glutaric acid potassium salt, with an acidic solution and removing a potassium ion from the glucaric acid potassium salt, (c) preparing an reaction admixture by adding the glucamide and a catalyst to hydrogen halide and acetic acid, and (d) treating the reaction admixture with hydrogen gas in a reactor thereby producing the adipamide.
Transfer Hydration of Dinitriles to Dicarboxamides
Naka, Hiroshi,Naraoka, Asuka
supporting information, p. 1977 - 1980 (2019/10/22)
We present a robust method for double transfer hydration of dinitriles to afford diamides. The transfer hydration of 1, n -dinitriles (n = 1-6) proceeds smoothly in the presence of a palladium(II) catalyst with acetamide as a water donor, affording the corresponding diamides in moderate to high yields, without involving significant side reactions such as monohydration or cyclization. The equilibrium was shifted in the forward direction by removing coproduced acetonitrile under reduced pressure.
