6280-34-8

Basic information

• Product Name: 5-cyclohexyl-2H-tetrazole
• CAS NO: 6280-34-8
• Molecular Formula: C₇H₁₂N₄
• Molecular Weight: 152.197
• Mol File: 6280-34-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 311°C at 760 mmHg
• Flash Point: 145°C
• Density: 1.183g/cm³
• Vapor Pressure: 0.000578mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 5-cyclohexyl-2H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-cyclohexyl-2H-tetrazole(6280-34-8)
• EPA Substance Registry System: 5-cyclohexyl-2H-tetrazole(6280-34-8)

Safety Data

• Hazardous Substances Data: 6280-34-8(Hazardous Substances Data)

Upstream product

• 18039-42-4 5-Phenyl-1H-tetrazole 
• 766-05-2 cyclohexane carbonitrile 
• 4715-11-1 cyclohexanecarbaldoxime 

Downstream Products

• 99993-12-1 [2-(5-cyclohexyl-tetrazol-2-yl)-ethyl]-dimethyl-amine 
• 143018-95-5 2-(5-cyclohexyltetrazol-2-yl)acetophenone 
• 143018-94-4 2-(5-cyclohexyltetrazol-1-yl)acetophenone 
• 142868-13-1 5-cyclohexyl-1-methyl-4-phenacyl-1H-tetrazolium iodide 

Relevant articles and documents

TMSN3-Bu2Sn(OAc)2: A modified and mild reagent system for Wittenberger tetrazole-synthesis

Treatments of various nitriles with TMSN3 and Bu2Sn(OAc)2 at 30 °C in benzene for 60 h yielded the corresponding 5-substituted 1H-tetrazoles in good to excellent yields. This method is a mild and efficient alternative reagent system for Wittenberger tetrazole-synthesis that uses TMSN3 and Bu2SnO in toluene at high temperature (93–110 °C) for 24–72 h.

Antibacterial assessment of heteroaryl, Vinyl, Benzyl, and Alkyl tetrazole compounds

Background: In previous reports, the antibacterial properties of certain tetrazole derivatives have been described. We have previously reported the antibacterial properties of aryl 1H-tetrazole compounds. Objective: To study the antibacterial activity of 5-substituted heteroaryl, vinyl, benzyl, and alkyl 1H-tetrazole derivatives. Methods: The antibacterial properties of heteroaryl, vinyl, benzylic, and aliphatic tetrazole derivatives were investigated against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The activity was assessed by determining the minimum inhibitory concentration of these tetrazole derivatives and comparing them to the known antibiotics amoxicillin, trimethoprim and sulfamethoxazole. Results: The tetrazole compounds were prepared utilizing cerium(III) chloride heptahydrate catalysis at 160o C for 1-4 h in a microwave reactor using an aqueous solvent mixture. The most active derivatives exhibited minimum inhibitory concentration values between 125-250 μg/mL against Escherichia coli. More importantly, these compounds were considerably more active when used in combination with trimethoprim and a significant synergistic effect was observed (MIC = 0.98-7.81 μg/mL) against E. coli and S. aureus. Conclusion: The tetrazole derivatives were synthesized in high yield and short reaction times in water. Several of the tetrazole compounds showed a significant synergistic antibacterial effect when used with trimethoprim.

Preparation of 5-substituted 1H-tetrazoles catalyzed by scandium triflate in water

Several 5-substituted 1H-tetrazoles were prepared in water or isopropanol/water mixtures using microwave heating. Good yields were obtained for the [2 + 3] cycloaddition of sodium azide with aryl nitriles, aliphatic nitriles, and vinyl nitriles when catal