6282-15-1

Basic information

• Product Name: 4-chloro-N-(3-nitrophenyl)benzamide
• Synonyms: benzamide, 4-chloro-N-(3-nitrophenyl)-
• CAS NO: 6282-15-1
• Molecular Formula: C₁₃H₉ClN₂O₃
• Molecular Weight: 276.6752
• Mol File: 6282-15-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 348.9°C at 760 mmHg
• Flash Point: 164.8°C
• Density: 1.44g/cm³
• Vapor Pressure: 4.87E-05mmHg at 25°C
• Refractive Index: 1.676
• CAS DataBase Reference: 4-chloro-N-(3-nitrophenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(3-nitrophenyl)benzamide(6282-15-1)
• EPA Substance Registry System: 4-chloro-N-(3-nitrophenyl)benzamide(6282-15-1)

Safety Data

• Hazardous Substances Data: 6282-15-1(Hazardous Substances Data)

Upstream product

• 1871-38-1 phenyl 4-chlorobenzoate 
• 99-09-2 3-nitro-aniline 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 905811-04-3 N-(3-amino-phenyl)-4-chloro-benzamide 
• 1192927-83-5 3,4,5-trimethoxy-N-((3-(4-chlorobenzoyl)aminophenylamino)carbonothioyl)benzamide 
• 1192928-19-0 N-(3-(4-chlorobenzoylamino-2-methylphenyl-amino)carbonyl)-3,4,5-trimethoxybenzamide 
• 330821-83-5 C₂₀H₁₅ClN₂O₂ 

Relevant articles and documents

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

TASK-1 is a two-pore domain potassium channel that is important to modulating cell excitability, most notably in the context of neuronal pathways. In order to leverage TASK-1 for therapeutic benefit, its physiological role needs better characterization; however, designing selective inhibitors that avoid the closely related TASK-3 channel has been challenging. In this study, a series of bis-amide derived compounds were found to demonstrate improved TASK-1 selectivity over TASK-3 compared to reported inhibitors. Optimization of a marginally selective hit led to analog 35 which displays a TASK-1 IC 50 = 16 nM with 62-fold selectivity over TASK-3 in an orthogonal electrophysiology assay.

A mild and efficient procedure for the conversion of aromatic carboxylic esters to secondary amides

A mild and efficient procedure has been developed for the conversion of aromatic carboxylic esters to secondary amides using reusable Zn dust with microwave heating in the presence of N,N-dimethylformamide or conventional heating by stirring in an oil bath using THF as solvent. Zn dust can be reused several times after simple washing with dil. HC1 and distilled water.